Transcatheter subendocardial infusion. A novel technique for mapping and ablation of ventricular myocardium

A GoetteJ J Langberg


Catheter ablation with radiofrequency energy is feasible in a limited subset of patients with ventricular tachycardia. The purpose of this study was to evaluate a technique for mapping and ablation of ventricular myocardium with the use of transcatheter subendocardial infusion. A needle-tipped deflectable electrode catheter was used to deliver reagents to endocardial target sites. This was equipped with two central lumens to allow sequential administration of mapping and ablation injectants with minimal admixture. The mapping injectant consisted of a mixture of lidocaine, iohexal, and glycerin; the ablation injectant contained ethanol, iohexal, and glycerin. Infusion of the mapping injectant (1 cm3 over 3 or 5 seconds, n = 14) produced a stain on fluoroscopy and increased local capture threshold by 61%. No lesions resulted from mapping infusions. Infusion of the ethanol-containing injectant (n = 48) produced discrete lesions, with a mean volume ranging from 0.6 to 1.5 cm3. There was a direct relationship between infusion volume, infusion duration, and resultant lesion volume. Fibrosis in a region of healed myocardial infarction did not impair diffusion of the injectant or affect lesion dimensions. Microscopic analysis of chroni...Continue Reading


Jun 1, 1997·Herzschrittmachertherapie & Elektrophysiologie·A GoetteJ J Langberg
Apr 1, 1997·Trends in Neurosciences·J Hardy
Feb 28, 2009·Artificial Organs·Petronio G ThomazNoedir A G Stolf
Feb 15, 2001·Echocardiography·Denis Pellerin, Colette Veyrat
Nov 19, 2003·Pacing and Clinical Electrophysiology : PACE·Aravinda ThiagalingamPramesh Kovoor
May 5, 2011·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Rui GuoJing Huang
Jun 8, 2015·Current Opinion in Cardiology·Paul SchurmannMiguel Valderrábano
Jun 26, 1998·Journal of Clinical Laser Medicine & Surgery·R J March


Oct 1, 1990·Pacing and Clinical Electrophysiology : PACE·J J LangbergM Rosenqvist
Jan 1, 1992·Journal of the American College of Cardiology·G N KayV J Plumb
Dec 1, 1991·European Heart Journal·B D GonskaH Kreuzer
Aug 15, 1991·The American Journal of Cardiology·H de SwartH J Wellens
Nov 1, 1988·Pacing and Clinical Electrophysiology : PACE·G T EvansG Fontaine
Dec 1, 1987·Journal of the American College of Cardiology·H InoueD P Zipes
May 15, 1994·The American Journal of Cardiology·D S HeM L Aguirre
Jan 1, 1994·Journal of Cardiovascular Electrophysiology·D E HainesJ P DiMarco

Related Concepts

Left Ventricular Structure
Isolated Noncompaction of the Ventricular Myocardium
Myocardial Infarction
Cardiac Surgery Procedures
Tachycardia, Ventricular

Related Feeds


Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Cardiology Journals

Discover the latest cardiology research in this collection of the top cardiology journals.