PMID: 3756160Oct 9, 1986Paper

Transcellular cross bonding of the red blood cell membrane

Biochimica Et Biophysica Acta
T M Fischer

Abstract

When red blood cells are osmotically shrunk, opposing regions of the inner membrane surface touch each other in the dimple area. In normal red cells such a mechanical contact is undone by reswelling the cells. When the cells are treated with the SH reagents diamide or N-ethylmaleimide, or simply heated to temperatures between 42 and 48 degrees C such a mechanical contact can be made permanent by a process termed 'membrane cross bonding'. Cross bonding also occurred when the cells were treated before mechanical contact was established. The bridge between the two cross-bonded membrane regions may be assumed to be formed by membrane skeletal material. Membrane bridges become visible microscopically when the cells are swollen. These bridges are strong enough to resist the membrane tensions occurring at osmotic lysis. Bridged red cells can be a useful tool in rheology, since they are deformable but cannot adapt to shear flows by membrane tank treading.

References

May 4, 1978·Biochimica Et Biophysica Acta·C W HaestB Deuticke
Jan 1, 1977·Journal of Biomechanics·P R ZardaR Skalak
Oct 1, 1972·Microvascular Research·E Evans, Y C Fung
Nov 1, 1968·The Journal of General Physiology·C M Gary-Bobo, A K Solomon
Jan 1, 1981·The Journal of Membrane Biology·S Jausel-Hüsken, B Deuticke
Apr 1, 1956·Journal of Cellular Physiology·A K PARPART, J F HOFFMAN
Sep 1, 1964·The Journal of General Physiology·D SAVITZA K SOLOMON

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Citations

Jan 1, 1994·Veterinary Clinical Pathology·William J. ReaganJohn Turek
Jan 7, 2005·Journal of the American Animal Hospital Association·Osamu YamatoYoshimitsu Maede
Aug 16, 2016·Biomechanics and Modeling in Mechanobiology·Thomas M Fischer
Sep 1, 1994·Veterinary Pathology·S L StockhamD A Kinden
Feb 3, 2018·Photomedicine and Laser Surgery·Amal Yousif Al-Yasiri

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