PMID: 11920906Mar 29, 2002Paper

Transcervical chorionic villus sampling in multiple pregnancies using a biopsy forceps

Prenatal Diagnosis
Gemma CasalsA Fortuny

Abstract

The aim of this study was to assess the effectiveness and safety of chorionic villus sampling (CVS) performed in multiple pregnancies by means of a transcervical biopsy forceps. The study included CVS performed from January 1990 to March 2000 in our Unit. The results were analysed in two consecutive periods, period A (1990-1994) and period B (1995-2000), in an attempt to assess the effect of increasing experience. Seventy-five samplings were performed in 39 multiple pregnancies, 38 twin sets and one triplet. A cytogenetic report was obtained in 73% of cases in period A and in 98% in period B. An abnormal karyotype was observed in 11 samples. The need for subsequent amniocentesis decreased from 38% in period A to 10% in period B. The spontaneous fetal loss rate in chromosomally and structurally normal fetuses before the 20th week decreased from 8.7% in period A to 3.3% in period B. The fetal loss rate after the 20th week was 3.3% in period B and none in period A. It must be noted that in three out of the four cases of fetal loss an amniocentesis was needed after CVS. Our results suggest that effectiveness and safety improved with increasing experience. Transcervical chorionic villus sampling allows an earlier prenatal genetic di...Continue Reading

Citations

Jun 1, 2005·Clinics in Perinatology·Meredith RochonJoanne Stone
Feb 4, 2014·Best Practice & Research. Clinical Obstetrics & Gynaecology·Alain Gagnon, Francois Audibert

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