Transcoronary bone marrow-derived progenitor cells in a child with myocardial infarction: first pediatric experience.

Clinical Cardiology
Alisa LimsuwanSarana Boonbaichaiyapruk

Abstract

Recent advances in stem cell therapy to restore cardiac function have great promise for patients with congestive heart failure after myocardial infarction in an adult population. We examined the benefits of bone marrow-derived progenitor cells treatment modality for the pediatric patient. We present our first case of transcoronary autologous stem cell transplantation in a 9-year-old girl with refractory congestive heart failure secondary to myocardial infarction 1 year after transcatheter revascularization. The child received daily injections of granulocyte colony-stimulating factor for 3 days prior to the bone marrow aspiration. The bone marrow cells were isolated to constitute CD133+/CD34+ more than 90% of the total number. Subsequently, the progenitor cell suspension was injected via a transcoronary catheter without any complication. Three months after stem cell therapy, her cardiac function, assessed by both cardiac magnetic resonance and echocardiogram, has been improved with the left ventricular ejection fraction at 47% compared to the baseline of 30%. This is the first reported pediatric case of successful transcoronary injection of bone marrow-derived progenitor cells for end-stage heart disease. The procedure is consid...Continue Reading

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Citations

Oct 12, 2010·Expert Opinion on Biological Therapy·Mirella MeregalliYvan Torrente
Jan 31, 2015·Pediatric Cardiology·Stefan Rupp, Dietmar Schranz
Oct 26, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Masoumeh GhafarzadehAli Eatemadi
Dec 22, 2017·Pediatrics International : Official Journal of the Japan Pediatric Society·Takahiro EitokuHidemasa Oh
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Apr 15, 2017·Circulation Research·Hidemasa Oh
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Jul 25, 2019·Current Opinion in Pediatrics·Daniel Bernstein
Mar 23, 2018·Heart Failure Reviews·Stefan Rupp, Christian Jux
Jul 5, 2016·Journal of Cardiovascular Development and Disease·Timothy J Nelson, Susana Cantero Peral
Jun 27, 2020·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Shuta IshigamiShunji Sano

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