Transcoronary Concentration Gradient of microRNA-133a and Outcome in Patients With Coronary Artery Disease

The American Journal of Cardiology
Roberta De RosaAndreas M Zeiher

Abstract

Circulating levels of microRNA (miR)-133a are increased in patients with coronary atherosclerotic disease (CAD). Whether the cardiac release of this miR provides any prognostic information in patients with CAD is currently unknown. We aimed to investigate if changes in concentration of miR-133a trough the coronary circulation may be associated with patients' cardiovascular outcome. We enrolled 111 patients (82 with stable CAD and 29 with acute coronary syndromes [ACS]) who underwent coronary angiography. Circulating levels of miR-133a were measured across the transcoronary circulation. Major adverse cardiac events (MACE: death, nonfatal myocardial infarction, and need for revascularization) were recorded through a median follow-up of 32 months. An increased transcoronary concentration gradient of miR133a showed a significant association with overall rate of MACE at follow-up in patients with both stable CAD and ACS (p = 0.011 and p = 0.002, respectively). At the single end point-analysis, increased transcoronary concentration gradients of miR133a were significantly associated with increased rate of death in patients with ACS (p = 0.017) and with increased incidence of new revascularization because of in-stent restenosis in pati...Continue Reading

Citations

Feb 2, 2018·Frontiers in Endocrinology·Salvatore De RosaDaniela P Foti
Jan 10, 2018·European Journal of Heart Failure·Salvatore De RosaAntonio Rapacciuolo
Jan 18, 2020·Briefings in Functional Genomics·Anu Radha SharmaPadmalatha S Rai
Dec 3, 2020·Archives of Medical Research·Shayan ZiaeeMohammadali Boroumand
Feb 28, 2020·Pharmacology & Therapeutics·Concetta SchianoClaudio Napoli
Jul 25, 2021·International Journal of Environmental Research and Public Health·Ceren EyiletenŁukasz A Małek
Jul 19, 2021·Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids·Richard J LightbodyAnnette Graham

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