Transcranial DC stimulation coupled with TENS for the treatment of chronic pain: a preliminary study

The Clinical Journal of Pain
Paulo S BoggioFelipe Fregni

Abstract

Based on evidence showing that electrical stimulation of the nervous system is an effective method to decrease chronic neurogenic pain, we aimed to investigate whether the combination of 2 methods of electrical stimulation-a method of peripheral stimulation [transcutaneous electrical nerve stimulation (TENS)] and a method of noninvasive brain stimulation [transcranial direct current stimulation (tDCS)]-induces greater pain reduction as compared with tDCS alone and sham stimulation. We performed a preliminary, randomized, sham-controlled, crossover, clinical study in which 8 patients were randomized to receive active tDCS/active TENS ("tDCS/TENS" group), active tDCS/sham TENS ("tDCS" group), and sham tDCS/sham TENS ("sham" group) stimulation. Assessments were performed immediately before and after each condition by a blinded rater. The results showed that there was a significant difference in pain reduction across the conditions of stimulation (P=0.006). Post hoc tests showed significant pain reduction as compared with baseline after the tDCS/TENS condition [reduction by 36.5% (+/-10.7), P=0.004] and the tDCS condition [reduction by 15.5% (+/-4.9), P=0.014], but not after sham stimulation (P=0.35). In addition, tDCS/TENS induced...Continue Reading

References

Jan 1, 1991·Pacing and Clinical Electrophysiology : PACE·T TsubokawaS Koyama
Nov 19, 1965·Science·R Melzack, P D Wall
Dec 26, 2001·Current Pain and Headache Reports·Keith G Rasmussen, Teresa A Rummans
Nov 19, 2003·The Journal of Pain : Official Journal of the American Pain Society·Barbara Rakel, Rita Frantz
Mar 18, 2004·Journal of Neurology, Neurosurgery, and Psychiatry·J-P LefaucheurJ-P Nguyen
Mar 5, 2005·The Journal of Physiology·Hugh BostockDavid Burke
Aug 19, 2005·Supplements to Clinical Neurophysiology·Jean-Pascal Lefaucheur
Jan 24, 2006·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Prateek C GandigaLeonardo G Cohen
Apr 25, 2006·Pain·Anne Louise Oaklander
Apr 13, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ciro Ramos-EstebanezAlvaro Pascual-Leone

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Citations

Oct 12, 2012·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Jacqueline BaileyCandida S McCabe
Nov 15, 2013·Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række·Asbjørn J FagerlundPer M Aslaksen
Sep 11, 2010·Expert Review of Clinical Immunology·Cheryl L WrightKim D Jones
Jul 15, 2015·Experimental and Therapeutic Medicine·Chunfang WuYong Chen
Apr 10, 2012·The Journal of Pain : Official Journal of the American Pain Society·Ela B PlowAndre Machado
Apr 21, 2012·The Journal of Pain : Official Journal of the American Pain Society·Jay S ReidlerFelipe Fregni
Nov 23, 2011·The Journal of Pain : Official Journal of the American Pain Society·Jeffrey J BorckardtMark S George
Dec 18, 2012·Neuromodulation : Journal of the International Neuromodulation Society·Ali ZandiehHamed Ekhtiari
Jul 4, 2015·Attention, Perception & Psychophysics·Thiago L CostaDora F Ventura
Oct 25, 2014·The Tohoku Journal of Experimental Medicine·Sea-Hyun BaeKyung-Yoon Kim
Dec 27, 2011·Manual Therapy·Siobhan M Schabrun, Lucinda S Chipchase
Jul 17, 2014·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Niran NgernyamParadee Auvichayapat
Jul 29, 2016·Cognitive Neurodynamics·Vesna Vuksanović, Philipp Hövel
Aug 12, 2016·Frontiers in Human Neuroscience·Antonino NaroAngelo Quartarone
Jan 15, 2011·Cephalalgia : an International Journal of Headache·Niels HansenZaza Katsarava
Mar 17, 2018·The Cochrane Database of Systematic Reviews·Neil E O'ConnellBenedict M Wand
Apr 15, 2014·The Cochrane Database of Systematic Reviews·Neil E O'ConnellLorraine H Desouza
Jun 10, 2018·The European Journal of Neuroscience·Sandra CarvalhoFelipe Fregni
Jun 29, 2018·The Journal of ECT·Camila Bonin PintoFelipe Fregni
Apr 14, 2018·The Cochrane Database of Systematic Reviews·Neil E O'ConnellBenedict M Wand
Feb 23, 2017·Hong Kong Physiotherapy Journal : Official Publication of the Hong Kong Physiotherapy Association Limited = Wu Li Chih Liao·Ghufran AlhassaniSiobhan S M Schabrun
Jan 27, 2019·Expert Review of Neurotherapeutics·Beatriz CostaFelipe Fregni
Jul 19, 2019·Journal of Neuroengineering and Rehabilitation·Isadora Santos FerreiraFelipe Fregni
Aug 28, 2020·Expert Review of Medical Devices·Kevin Pacheco-BarriosFelipe Fregni

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