Transcranial Direct Current Stimulation for Patients With Pharmacoresistant Epileptic Spasms: A Pilot Study

Frontiers in Neurology
Dongju YangYuping Wang

Abstract

Background: Epileptic spasms (ES) is a severe seizure type and lack of adequate methods for controlling of clinical attacks. Previous studies have indicated that cathodal transcranial direct current stimulation (tDCS) reduces seizure frequency for patients with epilepsy. ES are proposed to have a focal cortical origin. We hypothesized that patients with ES exhibit hyperactive network hubs in the parietal lobe, and that cathodal tDCS targeting the bilateral parietal region can reduce seizure frequency in patients with pharmacoresistant ES. Materials and Methods: The present study consisted of three basic phases: (a) a pre-treatment monitoring period for 14 days; (b) a consecutive 14-day treatment period during which patients were treated with 1 or 2 mA cathode tDCS for 40 min once per day; (c) and a follow-up period for at least 28 days. During the first 20 min of treatment, the cathode was placed over the right parietal lobe (P4) with the reference electrode over the contralateral supra-orbital area. In the second 20 min, the cathode was placed over the left parietal lobe (P3), with the reference electrode over the contralateral supra-orbital area. All patients received active tDCS treatment, and some patients underwent more th...Continue Reading

References

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Jul 19, 2018·Frontiers in Human Neuroscience·Patrick CiechanskiAdam Kirton

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Citations

Feb 15, 2021·Seizure : the Journal of the British Epilepsy Association·Pedro Sudbrack-OliveiraAndre Russowsky Brunoni
May 24, 2021·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Elisabeth KaufmannSoheyl Noachtar
Jul 15, 2021·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Daniel San-Juan

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