Transcranial direct current stimulation improves short-term memory in an animal model of attention-deficit/hyperactivity disorder

European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology
Douglas Teixeira LeffaIraci L S Torres

Abstract

Attention deficit hyperactivity disorder (ADHD) is characterized by impairing levels of hyperactivity, impulsivity and inattention. However, different meta-analyses have reported disruptions in short and long-term memory in ADHD patients. Previous studies indicate that mnemonic dysfunctions might be the result of deficits in attentional circuits, probably due to ineffective dopaminergic modulation of hippocampal synaptic plasticity. In this study we aimed to evaluate the potential therapeutic effects of a neuromodulatory technique, transcranial direct current stimulation (tDCS), in short-term memory (STM) deficits presented by the spontaneous hypertensive rats (SHR), the most widely used animal model of ADHD. Adult male SHR and Wistar Kyoto rats (WKY) were subjected to a constant electrical current of 0.5 mA intensity applied on the frontal cortex for 20 min/day during 8 days. STM was evaluated with an object recognition test conducted in an open field. Exploration time and locomotion were recorded, and brain regions were dissected to determine dopamine and BDNF levels. SHR spent less time exploring the new object when compared to WKY, and tDCS improved object recognition deficits in SHR without affecting WKY performance. Locom...Continue Reading

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Citations

Dec 15, 2016·Frontiers in Neuroscience·Suman DasOpher Donchin
Jul 18, 2018·Current Behavioral Neuroscience Reports·Carlos A Sánchez-LeónJavier Márquez-Ruiz
Jun 24, 2017·Menopause : the Journal of the North American Menopause Society·Mônia Steigleder BianchiMaria Celeste Osório Wender
Jul 13, 2018·Frontiers in Neuroscience·Sara CoccoClaudio Grassi
Nov 10, 2020·Journal of Alzheimer's Disease : JAD·Christopher B PopleNir Lipsman
Jul 23, 2020·Journal of Affective Disorders·Camila CosmoEduardo Pondé de Sena
Oct 3, 2018·Current Opinion in Biomedical Engineering·Carlos A Sánchez-LeónJavier Márquez-Ruiz

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