Transcranial direct current stimulation may modulate extinction memory in posttraumatic stress disorder

Brain and Behavior
Mascha Van't WoutBenjamin D Greenberg

Abstract

Abnormalities in fear extinction and recall are core components of posttraumatic stress disorder (PTSD). Data from animal and human studies point to a role of the ventromedial prefrontal cortex (vmPFC) in extinction learning and subsequent retention of extinction memories. Given the increasing interest in developing noninvasive brain stimulation protocols for psychopathology treatment, we piloted whether transcranial direct current stimulation (tDCS) during extinction learning, vs. during consolidation of extinction learning, might improve extinction recall in veterans with warzone-related PTSD. Twenty-eight veterans with PTSD completed a 2-day Pavlovian fear conditioning, extinction, and recall paradigm. Participants received one 10-min session of 2 mA anodal tDCS over AF3, intended to target the vmPFC. Fourteen received tDCS that started simultaneously with extinction learning onset, and the remaining 14 participants received tDCS during extinction consolidation. Normalized skin conductance reactivity (SCR) was the primary outcome measure. Linear mixed effects models were used to test for effects of tDCS on late extinction and early extinction recall 24 hr later. During early recall, veterans who received tDCS during extincti...Continue Reading

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Key Resources (RRID) Mentioned

SCR_014279
SCR_002865

Software Mentioned

SoterixMedical
Biopac Acqknowledge
Prime
Biopac
SPSS
tDCS Explore

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