Transcranial direct current stimulation (tDCS) facilitates verb learning by altering effective connectivity in the healthy brain

NeuroImage
Valentina FioriGesa Hartwigsen

Abstract

Recent studies have shown that the left inferior frontal gyrus (IFG) plays a key role in language learning. Facilitatory stimulation over this region by means of anodal transcranial direct current stimulation (tDCS) can modulate linguistic abilities in healthy individuals and improve language performance in patients with post-stroke aphasia. Neuroimaging studies in healthy participants have suggested that anodal tDCS decreases task-related activity at the stimulated site when applied during different language tasks, and changes resting-state connectivity in a larger network of areas associated with language processing. However, to date, the neural correlates of the potential beneficial effects of tDCS on verb learning remain unclear. The current study investigated how anodal tDCS during verb learning modulates task-related activity and effective connectivity in the healthy language network. To this end, we combined a verb learning paradigm during functional neuroimaging with simultaneous tDCS over the left IFG in healthy human volunteers. We found that, relative to sham stimulation, anodal tDCS significantly decreased task-related activity at the stimulated left IFG and in the right homologue. Effective connectivity analysis sh...Continue Reading

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Citations

Mar 11, 2020·Cognitive Processing·Lílian Rodrigues de AlmeidaPeter C Hansen
Mar 7, 2019·Frontiers in Psychology·Anke Ninija KarabanovHartwig Roman Siebner
Sep 29, 2020·Frontiers in Neurology·Shereen J MatarMarousa Pavlou
Dec 24, 2019·Frontiers in Psychology·Mohamed L SeghierClaudine Habak
Nov 27, 2020·Brain Communications·Rajani SebastianArgye E Hillis
Dec 17, 2020·Frontiers in Systems Neuroscience·Diego C NascimentoTaiza E G Santos
Mar 8, 2021·Cerebral Cortex·Philipp KuhnkeGesa Hartwigsen
Oct 16, 2020·Journal of Cognitive Neuroscience·Chong Zhao, Geoffrey F Woodman
Jun 25, 2021·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Sabrina Turker, Gesa Hartwigsen
Jul 17, 2021·Neuroscience and Biobehavioral Reviews·Maximilian A FriehsGesa Hartwigsen

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