Transcranial magnetic stimulation and antidepressive drugs share similar cellular effects in rat hippocampus

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
Y LevkovitzM Segal

Abstract

Transcranial magnetic stimulation (TMS) has been proposed as a safe and efficient treatment of human clinical depression. Although its antidepressive mechanism of action remained unknown, our previous studies indicate that TMS has a long-lasting effect on neuronal excitability in the hippocampus. We now compare the effects of chronic TMS with those of the antidepressant drugs desipramine and mianserin. The three treatments did not affect basal conduction in the perforant path to the dentate gyrus, but markedly suppressed paired-pulse and frequency-dependent inhibition, resulting from a reduction in local circuit inhibition in the dentate gyrus. Concomitantly, these treatments enhanced the expression of long-term potentiation in the perforant path synapse in the dentate gyrus. Finally, chronic TMS as well as mianserin suppressed the serotonin-dependent, potentiating action of fenfluramine on population spike in the dentate gyrus. Thus, TMS, mianserin, and desipramine are likely to affect the same neuronal populations, which may be relevant to their antidepressant action.

Citations

Aug 10, 2002·Journal of Psychosomatic Research·Gin S Malhi, Perminder Sachdev
Aug 19, 2003·Progress in Neuro-psychopharmacology & Biological Psychiatry·Eliyahu DremencovMichael E Newman
Sep 14, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Christopher Pittenger, Ronald S Duman
Jul 12, 2012·Neuromodulation : Journal of the International Neuromodulation Society·Andrew M Vahabzadeh-HaghAlexander Rotenberg
Mar 6, 2008·BMC Pharmacology·Andreas W HenkelJens Wiltfang
Mar 17, 2010·Molecular Neurodegeneration·Marwa AboukhatwaYuan Luo
Jun 1, 2006·Neuropsychiatric Disease and Treatment·Gin S MalhiPerminder Sachdev
Oct 25, 2008·Trends in Pharmacological Sciences·Vincenzo Di MarzoArpad Szallasi
Jan 24, 2007·Biological Psychiatry·Claus NormannMichael Bach
Mar 11, 2008·Biophysical Journal·Assaf Rotem, Elisha Moses
Dec 5, 2006·Biological Psychiatry·Roman HolderbachClaus Normann
Mar 15, 2005·Life Sciences·Kentaro KudoMitsuhiko Yamada
Feb 20, 2009·The International Journal of Neuropsychopharmacology·Rushaniya A KhairovaHusseini K Manji
Jul 2, 2003·Journal of Pharmacological Sciences·Satoshi OhashiMitsuhiro Yoshioka
Apr 22, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Xingbao LiMark S George
Oct 1, 2013·Reviews in the Neurosciences·Francisco Javier Medina, Isaac Túnez
Apr 20, 2017·International Review of Psychiatry·Marc Dubin
Feb 22, 2008·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Jane A Foster, Glenda MacQueen
Mar 21, 2017·Current Behavioral Neuroscience Reports·Marc J DubinFaith M Gunning
Jun 25, 2019·Journal of the Indian Institute of Science·Sanjna BanerjeeDevarajan Sridharan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.