Transcranial magnetic stimulation in obsessive-compulsive disorder: A focus on network mechanisms and state dependence

NeuroImage. Clinical
Luca CocchiMichael Breakspear

Abstract

Transcranial magnetic stimulation (TMS) is a non-invasive brain stimulation technique that has shown promise as an adjunct treatment for the symptoms of Obsessive-Compulsive Disorder (OCD). Establishing a clear clinical role for TMS in the treatment of OCD is contingent upon evidence of significant efficacy and reliability in reducing symptoms. We present the basic principles supporting the effects of TMS on brain activity with a focus on network-based theories of brain function. We discuss the promises and pitfalls of this technique as a means of modulating brain activity and reducing OCD symptoms. Synthesis of trends and critical perspective on the potential benefits and limitations of TMS interventions in OCD. Our critical synthesis suggests the need to better quantify the role of TMS in a clinical setting. The context in which the stimulation is performed, the neural principles supporting the effects of local stimulation on brain networks, and the heterogeneity of neuroanatomy are often overlooked in the clinical application of TMS. The lack of consideration of these factors may partly explain the variable efficacy of TMS interventions for OCD symptoms. Results from existing clinical studies and emerging knowledge about the...Continue Reading

Citations

Dec 5, 2019·Physics in Medicine and Biology·Jose Gomez-TamesShoogo Ueno
Aug 29, 2020·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Andrew Billnitzer, Joseph Jankovic
Jan 20, 2021·Nature Medicine·Shrey GroverRobert M G Reinhart
Apr 15, 2020·Brain Stimulation·Devin AdairMarom Bikson
May 16, 2020·Brain Stimulation·Marom BiksonHamed Ekhtiari

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Methods Mentioned

BETA
cognitive behavioural therapies
pharmacotherapies
SMA
cognitive behavioural therapy

Software Mentioned

ZUNG
SAS

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