Transcranial magnetic stimulation in patients with early cortical dementia: A pilot study

Annals of Indian Academy of Neurology
Thomas Gregor IssacB C Nagaraju

Abstract

The diagnostic accuracy of the currently available tools carries poor sensitivity resulting in significant delay in specific diagnosis of cortical dementias. Considering the properties of default mode networking of the brain it is highly probable that specific changes may be seen in frontotemporal dementias (FTDs) and Alzheimer's disease sufficiently early. The aim of this study is to look for changes in Transcranial Magnetic Stimulation (TMS) in cortical dementia. Evaluated with a single pulse TMS with the figure of eight coil and recorded from right first dorsal interossei (FDI). Resting Motor Threshold (RMT) was estimated on the opposite motor cortex (T1). Second site of stimulation was cervical spine at C7-T2. Central motor conduction time (CMCT) is equal toT1-T2. Silent Period (SP) identified by applying TMS pulse to contracting FDI. RMT was reduced in seven out of eight Alzheimer's dementias. CMCT was in the upper limit of normal in both patients with FTD. The most consistent observation was that SP was reduced and there were escape discharges noticed during the SP suggesting increased cortical excitability and decreased cortical inhibition. This suggests probable early asymptomatic changes in the gamma-aminobutyric acid ...Continue Reading

References

Jun 12, 2002·Neurology·E RatnavalliJ R Hodges
Jan 28, 2004·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·V Di LazzaroJ C Rothwell
Mar 18, 2004·Journal of Neurology, Neurosurgery, and Psychiatry·V Di LazzaroP A Tonali
Sep 8, 2004·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·M PierantozziA Stefani
Oct 7, 2006·Journal of Neural Transmission·R NardoneF Tezzon
Apr 10, 2008·Acta Neurologica Scandinavica·A AlbericiB Borroni
Aug 9, 2011·Dementia and Geriatric Cognitive Disorders·Raffaele NardoneEugen Trinka
Aug 13, 2011·Dementia and Geriatric Cognitive Disorders·Suvarna AlladiSubhash Kaul

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Citations

May 21, 2014·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Mariagiovanna CantoneVincenzo Di Lazzaro
May 19, 2017·Indian Journal of Psychological Medicine·Selva Ganapathy VelayuthamRavi Girikamatha Shankar
Nov 25, 2017·Journal of Alzheimer's Disease : JAD·Barbara BorroniAlessandro Padovani
Jun 16, 2017·Indian Journal of Psychological Medicine·Sadanandavalli Retnaswami ChandraThomas Gregor Issac
Nov 4, 2020·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Daniel R SchafferSerina A Neumann

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