Transcranial magnetic stimulation over the posterior cerebellum during smooth pursuit eye movements in man

Brain : a Journal of Neurology
K Ohtsuka, T Enoki

Abstract

Recent neurophysiological experiments in the monkey have demonstrated that the flocculus and the posterior vermis, lobules VIc-VII (oculomotor vermis), are involved in the generation of pursuit eye movements. Whereas the functions of the flocculus in the control of smooth pursuit have been intensively investigated, sufficient data are not available for a profitable discussion of the functions of the oculomotor vermis in the control of smooth pursuit. We previously indicated that the posterior vermis can be electrically stimulated by a focal transcranial magnetic stimulation (TMS) device through the skull in man, and that focal TMS of the posterior vermis can modulate saccadic eye movements. In this study we investigated the effects of cerebellar stimulation on smooth pursuit metrics in man using a focal TMS device. Focal TMS was applied over the posterior cerebellum in an area approximately 7 mm lateral and caudal to the inion, where saccadic eye movements are modulated by TMS, during horizontal smooth pursuit elicited by a step-ramp target with a constant velocity of 15 degrees/s in four normal subjects. The TMS device was triggered after the onset of smooth pursuit during the initial acceleration phase (latency range = 40-80 ...Continue Reading

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Citations

Jun 28, 2000·Microscopy Research and Technique·W H Nailon, J W Ironside
Jul 11, 2006·Experimental Brain Research·Maria A PastorAlvaro Pascual-Leone
Dec 6, 2006·Experimental Brain Research·Giacomo KochCarlo Caltagirone
Sep 11, 2007·Experimental Brain Research·Samuel B Hutton, Brendan S Weekes
Jul 4, 2012·The Cerebellum·Giorgos P Argyropoulos, Neil G Muggleton
May 18, 1999·Pediatric Neurology·L SztrihaM Nork
Jan 27, 2007·Cerebral Cortex·Anthony S Drew, Paul van Donkelaar
Jun 15, 2007·Schizophrenia Bulletin·Hernàn PicardMarie-Odile Krebs
Jul 30, 2010·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Eduard MinksMartin Bares
Mar 31, 1999·Current Opinion in Neurology·B Gaymard, C Pierrot-Deseilligny
Oct 26, 2005·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·A GironellC García-Sánchez
Oct 27, 2001·Acta Oto-laryngologica. Supplementum·W H Zangemeister, M Nagel
Mar 25, 2014·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Zaira CattaneoEgidio D'Angelo
Jul 12, 2018·Journal of Neurophysiology·Clara BourrellyLaurent Goffart
May 24, 2003·Brain : a Journal of Neurology·C HelmchenG Deuschl
Oct 17, 1998·Journal of Neurophysiology·M TakagiR J Tamargo
Dec 30, 2016·The Cerebellum·Kim van DunPeter Mariën
Dec 14, 2018·The Cerebellum·Sherry Y Tang, Aasef G Shaikh
Nov 7, 2019·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Ari A Shemesh, David S Zee
Aug 18, 2021·The Cerebellum·Gustavo V PonceDennis J L G Schutter

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