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Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation

Nature Biotechnology

May 1, 2010

Cole TrapnellLior Pachter

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Abstract

High-throughput mRNA sequencing (RNA-Seq) promises simultaneous transcript discovery and abundance estimation. However, this would require algorithms that are not restricted by prior gene annotations and that account for alternative transcription and splicing. Here we introduce such alg...read more

Mentioned in this Paper

Myoblasts
Homologous Gene
Protein Isoforms
Genome
RNA Splicing
MRNA Differential Display
Cdna Microarrays
Poly(A) Tail
Muscle Development
Transcriptome
6
5784
5
Paper Details
References
  • References27
  • Citations3412
12345...

Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation

Nature Biotechnology

May 1, 2010

Cole TrapnellLior Pachter

PMID: 20436464

DOI: 10.1038/nbt.1621

Abstract

High-throughput mRNA sequencing (RNA-Seq) promises simultaneous transcript discovery and abundance estimation. However, this would require algorithms that are not restricted by prior gene annotations and that account for alternative transcription and splicing. Here we introduce such alg...read more

Mentioned in this Paper

Myoblasts
Homologous Gene
Protein Isoforms
Genome
RNA Splicing
6
5784
5
Paper Details
References
  • References27
  • Citations3412
12345...

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