Abstract
Decreased expression of ten-eleven translocation (TET1, TET2 and TET3) proteins has been reported in various types of cancer. However, the expression levels of TET proteins in cervical cancer (CC) remain to be elucidated. The present study determined the levels of TET1, TET2 and TET3 transcripts in cancerous (n=80) and non-cancerous cervical tissues (n=41). The results revealed a significant reduction in TET1 transcripts (P=0.0000001) in cervical tissue samples from patients with primary CC compared with samples from control patients. Significantly decreased TET1 transcript levels, as compared to non-cancerous cervical tissues, were also observed in tissue samples with the following characteristics: Stage I (P=0.016), II (P<0.0001), III (P=0.00007) and grade of differentiation G1 (P=0.026), G2 (P=0.00006), G3 (P=0.0007) and Gx (P=0.0004) and squamous histological type (P<0.00001). TET1 transcript levels were significantly lower in patients aged 45-60 years (P=0.0002) and patients age >60 years (P=0.003), as compared with non-cancerous cervical tissues. TET2 transcript levels were lower in cervical cancer tissues classified as stage II (P=0.043) and TET3 transcript levels were lower in stage III samples (P=0.010), tissue samples...Continue Reading
References
Oct 23, 2001·International Journal of Cancer. Journal International Du Cancer·D M ParkinP Pisani
Jul 4, 2008·PloS One·Xiaohong WangZhi-Ming Zheng
Apr 18, 2009·Science·Mamta TahilianiAnjana Rao
May 8, 2009·Blood·Omar Abdel-WahabRoss L Levine
Jul 20, 2010·Nature·Shinsuke ItoYi Zhang
Jan 18, 2011·Cancer Biology & Therapy·Okechukwu A Ibeanu
Jun 4, 2011·Virology Journal·Rabia FaridiMuhammad Idrees
Aug 6, 2011·Science·Yu-Fei HeGuo-Liang Xu
Feb 11, 2012·Cancer Science·Yotaro KudoKazuhiko Koike
Mar 7, 2012·Oncogene·H YangY Xiong
Jun 13, 2012·The American Journal of Pathology·Tim MüllerAndreas Waha
Jun 19, 2012·Postȩpy higieny i medycyny doświadczalnej·Jolanta GuzRyszard Oliński
Sep 4, 2012·Clinical Epigenetics·Kathleen P SaavedraJuan Carlos S Roa
Sep 25, 2012·Cell Reports·Chih-Hung HsuLi-Jung Juan
May 15, 2013·PloS One·Chungang LiuCheng Qian
Feb 11, 2014·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Bartosz Adam FryczPaweł Piotr Jagodziński
Feb 20, 2014·BJOG : an International Journal of Obstetrics and Gynaecology·X ZhangZ Wang
Feb 21, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Jinchuan FangSufang Jin
Apr 17, 2014·Oncology Reports·Hilda Jiménez-WencesGloria Fernández-Tilapa
Aug 8, 2014·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Chunping DuHaruhiko Sugimura
Jan 6, 2015·Journal of Cancer Research and Clinical Oncology·Agnieszka Anna Rawłuszko-WieczorekPaweł Piotr Jagodziński
Jun 2, 2015·Aging and Disease·Igor Afanas'ev
Jul 15, 2015·Molecular Medicine Reports·Min FanXianlin Xu
Aug 16, 2015·Critical Reviews in Oncology/hematology·Agnieszka Anna Rawłuszko-WieczorekPaweł Piotr Jagodziński
Aug 26, 2015·Cytogenetic and Genome Research·Duo LiQianjin Lu
Sep 24, 2015·Stem Cell Research·Lizhi LiuXiajun Li
Nov 27, 2015·Nature Communications·Jungeun AnAnjana Rao
Dec 18, 2015·Bulletin of Mathematical Biology·Tri Sri Noor AsihJonathan Forde
Citations
Sep 14, 2019·Cancers·Matthias OckerRegine Schneider-Stock
Mar 27, 2020·Aging·Tingjuan ZhangJingdong Zhou
Aug 21, 2019·Cancers·Rakesh KumarM Radhakrishna Pillai
Apr 30, 2021·Journal of Cancer Research and Clinical Oncology·Jyoti ShekhawatMithu Banerjee