Transcript levels of ten-eleven translocation type 1-3 in cervical cancer and non-cancerous cervical tissues

Oncology Letters
Dorota Ewa Bronowicka-KłysPaweł Piotr Jagodziński

Abstract

Decreased expression of ten-eleven translocation (TET1, TET2 and TET3) proteins has been reported in various types of cancer. However, the expression levels of TET proteins in cervical cancer (CC) remain to be elucidated. The present study determined the levels of TET1, TET2 and TET3 transcripts in cancerous (n=80) and non-cancerous cervical tissues (n=41). The results revealed a significant reduction in TET1 transcripts (P=0.0000001) in cervical tissue samples from patients with primary CC compared with samples from control patients. Significantly decreased TET1 transcript levels, as compared to non-cancerous cervical tissues, were also observed in tissue samples with the following characteristics: Stage I (P=0.016), II (P<0.0001), III (P=0.00007) and grade of differentiation G1 (P=0.026), G2 (P=0.00006), G3 (P=0.0007) and Gx (P=0.0004) and squamous histological type (P<0.00001). TET1 transcript levels were significantly lower in patients aged 45-60 years (P=0.0002) and patients age >60 years (P=0.003), as compared with non-cancerous cervical tissues. TET2 transcript levels were lower in cervical cancer tissues classified as stage II (P=0.043) and TET3 transcript levels were lower in stage III samples (P=0.010), tissue samples...Continue Reading

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Citations

Sep 14, 2019·Cancers·Matthias OckerRegine Schneider-Stock
Aug 21, 2019·Cancers·Rakesh KumarM Radhakrishna Pillai
Apr 30, 2021·Journal of Cancer Research and Clinical Oncology·Jyoti ShekhawatMithu Banerjee

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