PMID: 8452879Mar 10, 1993Paper

Transcript levels of thymosin beta 4, an actin-sequestering peptide, in cell proliferation

Biochimica Et Biophysica Acta
A OteroJ Gómez-Márquez

Abstract

Thymosin beta 4 (beta 4) is an ubiquitous 5-kDa peptide that has been identified as an actin-sequestering peptide. In this work, Northern blot analysis was used to study the beta 4 mRNA levels during the cell cycle of rat thymocytes and hepatocytes as well as in human lymphocytes from patients with leukemia. beta 4 mRNA was found in all the stages of thymocyte and hepatocyte cell cycle, showing an increase in the S-phase which was maintained during the G2 and M phases. Incubation of splenic T-cells with concanavalin A, phorbol myristate acetate or the ionophore A23187 lead to a similar increase of beta 4 transcript during the S-phase. The increase in beta 4 mRNA observed in the G2/M boundary of the cell cycle, together with its ability to inhibit actin polymerization, suggests a possible role of beta 4 in the the morphological changes and actin redistribution occurring during the cytokinesis.

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Citations

Feb 1, 1994·Amino Acids·M Mihelić, W Voelter
Apr 20, 2001·The International Journal of Biochemistry & Cell Biology·T HuffE Hannappel
Feb 1, 1995·Cell Proliferation·J B ZalvideF Domínguez
Feb 7, 2012·Veterinary Parasitology·Yun-Jeong KangMee Sun Ock
Feb 12, 2005·World Journal of Surgery·Changyi ChenQizhi Yao
Jul 1, 1994·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·D Safer, V T Nachmias

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