PMID: 7541910Jun 25, 1995Paper

Transcription and processing of the rodent ID repeat family in germline and somatic cells

Nucleic Acids Research
J KimP L Deininger

Abstract

ID elements comprise a rodent SINE (short interspersed DNA repetitive element) family that has amplified by retroposition of a few master genes. In order to understand the important factors of SINE amplification, we investigated the transcription of rat ID elements. Three different size classes of ID transcripts, BC1, BC2 and T3, have been detected in various rat tissues, including brain and testes. We have analysed the nucleotide sequences of testes- and brain-derived ID transcripts isolated by size-fractionation, C-tailing and RACE. Nucleotide sequence variation of testes ID transcripts demonstrated derivation from different loci. However, the transcripts represent a preferred set of ID elements that closely match the subfamily consensus sequences. The small ID transcripts, T3, are not comprised of primary transcripts, but are instead processed polyA-transcripts generated from many different loci. These truncated transcripts would be expected to be retroposition-incompetent forms. Therefore, the amplification of ID elements is likely to be regulated at multiple steps of retroposition, which include transcription and processing. Although brain ID transcripts showed a similar pattern, with the addition of very high levels of tr...Continue Reading

References

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Jul 11, 1991·Nucleic Acids Research·M A BatzerP L Deininger
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Citations

Dec 1, 1996·Plant Molecular Biology·J M DeragonG Picard
Jan 1, 1995·Virus Genes·J Brosius, H Tiedge
Sep 4, 2009·Chromosoma·Dave A Pai, David R Engelke
Jul 30, 2004·Nucleic Acids Research·Thierry PélissierJean-Marc Deragon
Sep 15, 2004·Genome Research·Jürgen SchmitzJürgen Brosius
Aug 29, 2003·Molecular and Cellular Biology·Boris V SkryabinJürgen Brosius
Dec 12, 2012·Trends in Biochemical Sciences·Anna Iacoangeli, Henri Tiedge
Oct 7, 2011·Wiley Interdisciplinary Reviews. RNA·Dmitri A Kramerov, Nikita S Vassetzky
Mar 27, 2016·Nucleic Acids Research·Yicong MengZhifeng Shao
Jun 25, 1999·Molecular Genetics and Metabolism·P L Deininger, M A Batzer
Jun 19, 2007·Genomics·David H Kass, Nicole Jamison
Aug 31, 2000·Journal of Molecular Biology·A M RoyP L Deininger
Sep 7, 2002·The Journal of Biological Chemistry·Weiwen GeRafaela Canete-Soler
Oct 14, 2005·Molecular Biology and Evolution·Louise J Johnson, John F Y Brookfield
Aug 15, 1997·Journal of Molecular Biology·T H ShaikhP L Deininger

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