Transcription and splicing: A two-way street.

Wiley Interdisciplinary Reviews. RNA
Michael TellierShona Murphy

Abstract

RNA synthesis by RNA polymerase II and RNA processing are closely coupled during the transcription cycle of protein-coding genes. This coupling affords opportunities for quality control and regulation of gene expression and the effects can go in both directions. For example, polymerase speed can affect splice site selection and splicing can increase transcription and affect the chromatin landscape. Here we review the many ways that transcription and splicing influence one another, including how splicing "talks back" to transcription. We will also place the connections between transcription and splicing in the context of other RNA processing events that define the exons that will make up the final mRNA. This article is categorized under: RNA Processing > Splicing Mechanisms RNA Processing > Splicing Regulation/Alternative Splicing.

References

Aug 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·S M BergetP A Sharp
Jan 1, 1978·Cold Spring Harbor Symposia on Quantitative Biology·P J CurtisC Weissmann
Mar 1, 1991·Trends in Genetics : TIG·S W Ruby, J Abelson
Jan 1, 1990·Molecular and Cellular Biology·B L RobbersonS M Berget
Nov 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·I Edery, N Sonenberg
Feb 10, 1995·The Journal of Biological Chemistry·S M Berget
Jul 9, 1996·Proceedings of the National Academy of Sciences of the United States of America·A YuryevJ L Corden
Aug 6, 1996·Proceedings of the National Academy of Sciences of the United States of America·M J MortillaroR Berezney
May 1, 1997·Genes & Development·K M Neugebauer, M B Roth
May 18, 1999·The EMBO Journal·N CustódioM Antoniou
May 27, 1999·Genes & Development·Y HiroseJ L Manley
Jul 26, 2000·Proceedings of the National Academy of Sciences of the United States of America·S M CartyA L Greenleaf
Jun 7, 2002·Molecular Cell·Donny D LicatalosiDavid L Bentley
Sep 7, 2002·Molecular and Cellular Biology·A AudibertF Dautry
Sep 11, 2002·The Journal of Biological Chemistry·Guadalupe NoguesAlberto R Kornblihtt
Dec 20, 2002·Journal of Structural Biology·Olivia DoyleJoseph G Gall
Aug 5, 2003·Molecular and Cellular Biology·Kimberly M KotovicKarla M Neugebauer
Aug 28, 2003·Nature Structural Biology·Stephen Buratowski
Oct 11, 2003·Molecular Cell·Manuel de la MataAlberto R Kornblihtt
Feb 18, 2004·Molecular Cell·Stephanie C SchroederDavid Bentley

❮ Previous
Next ❯

Citations

Jun 18, 2020·International Journal of Molecular Sciences·Emmanuel AmpofoMatthias W Laschke
Jan 9, 2021·RNA Biology·Yi RanChengguo Yao
Feb 16, 2021·Frontiers in Genetics·Katherine A WoodRaymond T O'Keefe
Jan 16, 2021·Science·Suyang ZhangPatrick Cramer
Feb 13, 2021·NAR Genomics and Bioinformatics·Usama AshrafNadia Naffakh
Mar 11, 2021·Molecular Cell·Livia CaizziPatrick Cramer
Mar 7, 2021·International Journal of Molecular Sciences·Izarbe Aísa-MarínGemma Marfany
Apr 4, 2021·International Journal of Molecular Sciences·Jing YangLigeng Ma
Jun 2, 2021·Biochemical Society Transactions·Dale W MaxwellKathryn E Hentges
Jul 18, 2021·Human Mutation·Cristina Perez-BecerrilMiriam J Smith

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alternative splicing

Alternative splicing a regulated gene expression process that allows a single genetic sequence to code for multiple proteins. Here is that latest research.

Related Papers

Wiley Interdisciplinary Reviews. RNA
Sara Nik, Teresa V Bowman
Wiley Interdisciplinary Reviews. RNA
Patricia P ColtriGuilherme H G da Silva
Trends in Cell Biology
Fernando Carrillo OesterreichKarla M Neugebauer
© 2021 Meta ULC. All rights reserved