Transcription by Methanothermobacter thermautotrophicus RNA polymerase in vitro releases archaeal transcription factor B but not TATA-box binding protein from the template DNA

Journal of Bacteriology
Yunwei Xie, John N Reeve

Abstract

Transcription initiation in Archaea requires the assembly of a preinitiation complex containing the TATA- box binding protein (TBP), transcription factor B (TFB), and RNA polymerase (RNAP). The results reported establish the fate of Methanothermobacter thermautotrophicus TBP and TFB following transcription initiation by M. thermautotrophicus RNAP in vitro. TFB is released after initiation, during extension of the transcript from 4 to 24 nucleotides, but TBP remains bound to the template DNA. Regulation of archaeal transcription initiation by a repressor competition with TBP for TATA-box region binding must accommodate this observation.

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Citations

Feb 12, 2008·Journal of Bacteriology·Elizabeth A KarrJohn N Reeve
Jun 19, 2013·Annual Review of Microbiology·Kimberly B Decker, Deborah M Hinton
May 27, 2005·Molecular Microbiology·E Peter Geiduschek, Mohamed Ouhammouch
Jan 22, 2011·Critical Reviews in Biochemistry and Molecular Biology·Sung-Hoon JunKatsuhiko S Murakami
Aug 14, 2018·Nucleic Acids Research·Stefan DexlMichael Thomm

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