Transcription elements and functional expression of proopiomelanocortin genes in the pituitary gland of the barfin flounder

General and Comparative Endocrinology
Yuki KobayashiAkiyoshi Takahashi

Abstract

Proopiomelanocortin (POMC) is the precursor of adrenocorticotropin, melanocyte-stimulating hormone, and endorphin. Barfin flounder Verasper moseri possesses three POMC mRNAs. In this study, we determined the amino acid sequences of POMC-A, POMC-B, and POMC-C in this fish and investigated the effects of black or white background on the expression of these genes. The three POMC genes (POMCs) were composed of three exons and two introns, wherein all the hormonal segments were encoded on the third exon, a pattern similar to that in other vertebrates. Intron B of POMC-A and POMC-B contained microsatellites of CA repeats, indicating that these two genes diverged from a common immediate ancestor by a recent duplication event. The 5'-flanking regions of the POMC-A (-1051 to -1), POMC-B (-1465 to -1), and POMC-C (-870 to -1) genes contained TATA boxes, Tpit, cyclic AMP response element-like elements, E boxes, and other elements. POMC-B and POMC-C also contained CCAAT boxes. The expression of the three POMCs seems to be regulated by synergistic interactions among a variety of transcription factors. The transfer of barfin flounder between tanks with different colors showed that in response to a black or white background, the expression of...Continue Reading

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Jun 28, 2005·General and Comparative Endocrinology·Akiyoshi TakahashiHiroshi Kawauchi
Jul 26, 2005·General and Comparative Endocrinology·Akiyoshi TakahashiHiroshi Kawauchi
Oct 26, 2005·General and Comparative Endocrinology·Akiyoshi TakahashiHiroshi Kawauchi
Nov 18, 2005·General and Comparative Endocrinology·Akiyoshi Takahashi, Hiroshi Kawauchi
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Citations

Dec 28, 2010·General and Comparative Endocrinology·Kanta MizusawaAkiyoshi Takahashi
Apr 27, 2010·General and Comparative Endocrinology·Yuki KobayashiAkiyoshi Takahashi
Dec 15, 2010·General and Comparative Endocrinology·J C R CardosoD M Power
Nov 6, 2013·General and Comparative Endocrinology·Rayna M HarrisHans A Hofmann
Mar 26, 2013·General and Comparative Endocrinology·Akiyoshi TakahashiKanta Mizusawa
Dec 27, 2011·General and Comparative Endocrinology·Yuki KobayashiAkiyoshi Takahashi
Jun 26, 2017·General and Comparative Endocrinology·Kanta MizusawaAkiyoshi Takahashi

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