Transcription elongation. Heterogeneous tracking of RNA polymerase and its biological implications

Transcription
Masahiko ImashimizuMikhail Kashlev

Abstract

Regulation of transcription elongation via pausing of RNA polymerase has multiple physiological roles. The pausing mechanism depends on the sequence heterogeneity of the DNA being transcribed, as well as on certain interactions of polymerase with specific DNA sequences. In order to describe the mechanism of regulation, we introduce the concept of heterogeneity into the previously proposed alternative models of elongation, power stroke and Brownian ratchet. We also discuss molecular origins and physiological significances of the heterogeneity.

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Citations

Apr 8, 2015·Proceedings of the National Academy of Sciences of the United States of America·Christophe PennoJohn F Atkins
May 15, 2015·Biomolecules·Katsuhiko S Murakami
May 16, 2019·Biochemical Society Transactions·Maria Puiu, Christina Julius
Sep 24, 2015·Critical Reviews in Biochemistry and Molecular Biology·Liang XuDong Wang
Nov 11, 2016·Proceedings of the National Academy of Sciences of the United States of America·Masahiko ImashimizuDavid B Lukatsky
Aug 31, 2017·Transcription·Yuri A NedialkovZachary F Burton
Nov 25, 2016·Frontiers in Molecular Biosciences·Jookyung Lee, Sergei Borukhov
Nov 29, 2020·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Masahiko ImashimizuHiromichi Hoshina
Apr 1, 2021·Nucleic Acids Research·Martyna GajosAndreas Mayer
Apr 27, 2021·Frontiers in Molecular Biosciences·Nikita Fernandes, J Ross Buchan

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Methods Mentioned

BETA
NMR
X-ray
ChIP-chip

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