Abstract
Transcription factor 7-like 2 (TCF7L2) protein plays an important role in glucose and lipid metabolisms. Single nucleotide polymorphisms (SNPs) in the TCF7L2 gene contribute to increased fasting plasma glucose (FPG) and body mass index (BMI), and altered lipid concentrations in various population. We investigated whether the TCF7L2 SNPs were associated with obesity, high FPG and altered lipid profile in the Balinese. A total of 608 Balinese from rural and urban Bali, Indonesia, were recruited. Triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), total cholesterol (TC) and FPG were measured, and BMI was calculated. Ratios of TG/HDL-C, LDL-C/HDL-C, and TC/HDL-C were determined. Genotyping of SNPs rs7903146, rs10885406, and rs12255372 were done in all samples. Genetic association analyses under a dominant model showed that the rs7903146 (OR 5.50, 95% CI 2.34-12.91, p = 8.5 × 10-5), rs12255372 (OR 4.15, 95% CI 1.66-10.33, p = 0.003) and rs10885406 (OR 2.43, 95% CI 1.39-4.25, p = 0.003) were significantly associated with high TC/HDL-C ratio. The rs10885406 also presented a significant association with high TG (OR 2.21, 95% CI 1.29-3.81, p = 0.004) and low HDL-C (OR 3.02, 95% ...Continue Reading
References
Dec 25, 2002·Bioinformatics·S PurcellP C Sham
Jan 2, 2003·Proceedings of the National Academy of Sciences of the United States of America·Takahiro FujinoTokuo T Yamamoto
Nov 6, 2003·Statistical Methods in Medical Research·Thomas Nichols, Satoru Hayasaka
Dec 25, 2003·Diabetes Care·UNKNOWN American Diabetes Association
Apr 10, 2004·Bioinformatics·Owen J Marshall
Dec 1, 2005·Annals of Human Biology·A C HuntsmanK Gunung
Jan 18, 2006·Nature Genetics·Struan F A GrantKari Stefansson
Jun 24, 2006·The Journal of Biological Chemistry·Michael D Gordon, Roel Nusse
Nov 10, 2006·Diabetologia·G R ChandakC S Yajnik
Jan 9, 2007·Nature Genetics·Agnar HelgasonKári Stefánsson
Jan 25, 2007·Diabetologia·M HorikoshiT Kadowaki
Feb 3, 2007·Bioinformatics·Juan R GonzálezVíctor Moreno
Jun 21, 2007·Diabetes·Yi-Cheng ChangLee-Ming Chuang
Aug 3, 2007·The Journal of Clinical Investigation·Valeriya LyssenkoLeif Groop
Feb 20, 2008·Diabetes Research and Clinical Practice·Hussein SaadiM Gary Nicholls
Apr 10, 2008·Annals of Human Genetics·D K SangheraM I Kamboh
Apr 26, 2008·Diabetologia·S J BielinskiE Boerwinkle
Nov 15, 2008·Trends in Endocrinology and Metabolism : TEM·Constantinos ChristodoulidesAntonio Vidal-Puig
Dec 6, 2008·BMC Medical Genetics·G F MarquezineJ E Krieger
Jul 16, 2009·Human Molecular Genetics·Ludmila Prokunina-OlssonJennifer L Hall
Jul 21, 2009·Journal of the Cardiometabolic Syndrome·Henry N Ginsberg, Paul R MacCallum
Jan 19, 2010·Nature Genetics·Josée DupuisInês Barroso
Jan 26, 2010·The Journal of Clinical Endocrinology and Metabolism·Ashis K MondalSteven C Elbein
May 31, 2011·BMC Research Notes·Safarina G MalikHerawati Sudoyo
Oct 14, 2011·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Ketut SuastikaHiroshi Taniguchi
Mar 28, 2012·The American Journal of Cardiology·Martin R SalazarGerald M Reaven
Apr 27, 2012·Cardiovascular Diabetology·Sukma OktavianthiSafarina G Malik
May 4, 2012·The American Journal of Clinical Nutrition·Eva FisherHeiner Boeing
May 16, 2012·Genetic Testing and Molecular Biomarkers·Vipin GuptaMohinder Pal Sachdeva
Sep 4, 2012·Journal of Genetics·Watip TangjittipokinPa-Thai Yenchitsomanus
Oct 23, 2012·Diabetes·Dorota KaminskaJussi Pihlajamäki
Nov 22, 2014·Nucleic Acids Research·Luke NortonSami Heikkinen
Jan 21, 2015·Journal of Endocrinological Investigation·Z HertelyovaP Kruzliak
Apr 9, 2015·EMBO Reports·Cameron C ScottJean Gruenberg
Dec 1, 2015·Diabetes & Metabolism Journal·Mohammad PourahmadiAbdolreza Sotoodeh Jahromi
Mar 10, 2016·Nature Communications·Chuntao ZhaoQ Richard Lu
Feb 22, 2017·Scientific Reports·L EngelbrechtsenH Vestergaard
Mar 30, 2017·Experimental and Therapeutic Medicine·Hugo Leonid Gallardo-BlancoLaura Elia Martinez-Garza
Jun 15, 2017·Diabetes Care·Catrina CropanoSonia Caprio
Nov 29, 2017·PloS One·Dhanasekaran BodhiniKarani Santhanakrishnan Vimaleswaran