Transcription factor GATA-4 is a marker of anaplasia in adrenocortical neoplasms of the domestic ferret (Mustela putorius furo)

Veterinary Pathology
R A PetersonD B Wilson

Abstract

Adrenocortical neoplasms are a common cause of morbidity in neutered ferrets. Recently we showed that gonadectomized DBA/2J mice develop adrenocortical tumors that express transcription factor GATA-4. Therefore, we screened archival specimens of adrenocortical neoplasms from neutered ferrets to determine whether GATA-4 could be used as a tumor marker in this species. Nuclear immunoreactivity for GATA-4 was evident in 19/22 (86%) of ferret adrenocortical carcinomas and was prominent in areas exhibiting myxoid differentiation. Normal adrenocortical cells lacked GATA-4 expression. Two other markers of adrenocortical tumors in gonadectomized mice, inhibin-alpha and luteinizing hormone receptor, were coexpressed with GATA-4 in some of the ferret tumors. No GATA-4 expression was observed in three cases of nodular hyperplasia, but patches of anaplastic cells expressing GATA-4 were evident in 7/14 (50%) of tumors classified as adenomas. We conclude that GATA-4 can function as a marker of anaplasia in ferret adrenocortical tumors.

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Citations

Jan 5, 2008·Molecular Endocrinology·Robert S VigerMarkku Heikinheimo
Jan 9, 2007·Molecular and Cellular Endocrinology·Helka ParviainenMarkku Heikinheimo
Sep 11, 2013·The Veterinary Clinics of North America. Exotic Animal Practice·Sari Kanfer, Drury R Reavill
Nov 22, 2011·Molecular and Cellular Endocrinology·Felix BeuschleinDavid B Wilson
Feb 18, 2010·The Veterinary Clinics of North America. Exotic Animal Practice·Sharman M Hoppes
Jan 1, 2008·The Veterinary Clinics of North America. Exotic Animal Practice·Elisabeth Simone-Freilicher
Mar 6, 2007·Molecular and Cellular Endocrinology·Susanna VuorenojaNafis A Rahman
Mar 17, 2007·Molecular and Cellular Endocrinology·Harold E Carlson
Jan 13, 2006·The Veterinary Clinics of North America. Exotic Animal Practice·Peter G Fisher
Oct 8, 2014·Molecular and Cellular Endocrinology·Maximiliaan SchillebeeckxDavid B Wilson
Dec 17, 2014·Molecular and Cellular Endocrinology·Theresa RöhrigDavid B Wilson
Mar 16, 2005·Molecular and Cellular Endocrinology·Sanne KiiveriMarkku Heikinheimo
Mar 5, 2016·Veterinary Pathology·V BakthavatchaluJ G Fox
May 12, 2009·Veterinary Pathology·J A Ramos-Vara, M A Miller
Sep 22, 2018·Veterinary Clinical Pathology·Charalampos AttipaLaureen M Peters
May 28, 2005·Endocrinology·Malgorzata BielinskaDavid B Wilson
Mar 31, 2012·Endocrinology·Justyna KrachulecDavid B Wilson
Jan 26, 2005·Endocrine Research·S KiiveriM Heikinheimo

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Methods Mentioned

BETA
biopsy

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