Transcription factor interactions: selectors of positive or negative regulation from a single DNA element

Science
M I DiamondK R Yamamoto

Abstract

The mechanism by which a single factor evokes opposite regulatory effects from a specific DNA sequence is not well understood. In this study, a 25-base pair element that resides upstream of the mouse proliferin gene was examined; it conferred on linked promoters either positive or negative glucocorticoid regulation, depending upon physiological context. This sequence, denoted a "composite" glucocorticoid response element (GRE), was bound selectively in vitro both by the glucocorticoid receptor and by c-Jun and c-Fos, components of the phorbol ester-activated AP-1 transcription factor. Indeed, c-Jun and c-Fos served as selectors of hormone responsiveness: the composite GRE was inactive in the absence of c-Jun, whereas it conferred a positive glucocorticoid effect in the presence of c-Jun, and a negative glucocorticoid effect in the presence of c-Jun and relatively high levels of c-Fos. The receptor also interacted selectively with c-Jun in vitro. A general model for composite GRE action is proposed that invokes both DNA binding and protein-protein interactions by receptor and nonreceptor factors.

References

Apr 1, 1990·Genes & Development·J D SafferS J Thurston
Apr 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·M VaccaroJ P Jost
Dec 1, 1988·Genes & Development·F J RauscherT Curran
Nov 3, 1989·Cell·M Levine, J L Manley
Feb 10, 1989·Cell·M Beato
Jan 1, 1987·Molecular Endocrinology·J N VanderbiltK R Yamamoto
Nov 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·T R FuerstB Moss
Dec 1, 1987·Experimental Cell Research·T J Lockett, M J Sleigh
Jan 1, 1985·Annual Review of Genetics·K R Yamamoto
Apr 1, 1973·Virology·F L Graham, A J van der Eb

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Citations

Aug 1, 1994·Arthritis and Rheumatism·M P VincentiC E Brinckerhoff
Jan 1, 1992·Bioelectromagnetics·G S Stein, J B Lian
Apr 1, 1993·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·J R Tata
May 1, 1996·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·A C Cato, E Wade
May 1, 1992·Journal of Cellular Biochemistry·J B Lian, G S Stein
Sep 1, 1992·Journal of Cellular Biochemistry·J R PerezK R Cutroneo
Feb 1, 1993·Journal of Cellular Biochemistry·K L Burnstein, J A Cidlowski
Jun 1, 1994·Journal of Cellular Biochemistry·J P LandersT C Spelsberg
Nov 1, 1994·Journal of Cellular Biochemistry·A M DelanyE Canalis
Aug 1, 1993·Protein Science : a Publication of the Protein Society·A D Strosberg
Oct 1, 1994·Plant Molecular Biology·P F StraubT D Ho
Jan 1, 1992·Mammalian Genome : Official Journal of the International Mammalian Genome Society·D M SeverynseM H Edgell
Jan 1, 1993·Breast Cancer Research and Treatment·M G Parker
Dec 1, 1992·Cellular and Molecular Neurobiology·T IglesiasJ A Fuentes
Jan 1, 1997·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·G H Williams
Jan 1, 1993·European Journal of Clinical Pharmacology·M KarinF Saatcioglu
May 1, 1996·Behavior Genetics·J M KornhauserJ S Takahashi
Mar 29, 2005·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Jianbo LiuHuilan Zhang
Apr 1, 1995·Endocrine·V R MartinsP R Housley
Aug 6, 2011·Breast Cancer Research and Treatment·Myriam VilascoAnne Gompel
Jun 8, 2007·Cellular and Molecular Neurobiology·Gregg R WardAllyn C Howlett
Apr 1, 1996·Steroids·M BeatoM Truss
Oct 1, 1992·Journal of Neuroimmunology·F Russo-Marie

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