Transcription factor IRF1 is responsible for IRF8-mediated IL-1β expression in reactive microglia

Journal of Pharmacological Sciences
Takahiro MasudaKazuhide Inoue

Abstract

Interferon regulatory factor-8 (IRF8) plays a crucial role in the transformation of microglia to a reactive state by regulating the expression of various genes. In the present study, we show that IRF1 is required for IRF8-induced gene expression in microglia. Peripheral nerve injury induced IRF1 gene upregulation in the spinal microglia in an IRF8-dependent manner. IRF8 transduction in cultured microglia induced de novo gene expression of IRF1. Importantly, knockdown of the IRF1 gene in IRF8-transduced microglia prevented upregulation of interleukin-1β (IL-1β). Therefore, our findings suggest that expression of IL-1β is dependent on IRF1 in IRF8-expressing reactive microglia.

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Citations

Sep 1, 2017·Journal of Molecular Neuroscience : MN·Qinggan ZengXiaofeng Wang
Feb 9, 2018·Nature Reviews. Neuroscience·Kazuhide Inoue, Makoto Tsuda
Jul 28, 2020·Cells·José A Rodríguez-GómezMiguel A Burguillos
Aug 2, 2017·The Journal of Clinical Investigation·Inge R HoltmanChristopher K Glass
Jul 17, 2019·BioMed Research International·Yajuan LiLingzhi Yu
Dec 4, 2019·Biological & Pharmaceutical Bulletin·Makoto Tsuda
Feb 20, 2019·Frontiers in Pharmacology·Sailesh PalikheYuichi Hattori
Jun 11, 2019·Frontiers in Immunology·Aleksandra AntonczykHans A R Bluyssen
Jul 5, 2016·Journal of Neuroscience Research·Makoto Tsuda
May 14, 2021·Pain Reports·Keita Kohno, Makoto Tsuda
Aug 3, 2021·Computers in Biology and Medicine·M Babul IslamMohammad Ali Moni

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