Transcription factor kinetics and the emerging asymmetry in the early mammalian embryo

Cell Cycle
Periklis Pantazis, Tobias Bollenbach

Abstract

There is a long-running controversy about how early cell fate decisions are made in the developing mammalian embryo. ( 1) (,) ( 2) In particular, it is controversial when the first events that can predict the establishment of the pluripotent and extra-embryonic lineages in the blastocyst of the pre-implantation embryo occur. It has long been proposed that the position and polarity of cells at the 16- to 32-cell stage embryo influence their decision to either give rise to the pluripotent cell lineage that eventually contributes to the inner cell mass (ICM), comprising the primitive endoderm (PE) and the epiblast (EPI), or the extra-embryonic trophectoderm (TE) surrounding the blastocoel. The positioning of cells in the embryo at this developmental stage could largely be the result of random events, making this a stochastic model of cell lineage allocation. Contrary to such a stochastic model, some studies have detected putative differences in the lineage potential of individual blastomeres before compaction, indicating that the first cell fate decisions may occur as early as at the 4-cell stage. Using a non-invasive, quantitative in vivo imaging assay to study the kinetic behavior of Oct4 (also known as POU5F1), a key transcript...Continue Reading

References

Mar 1, 1977·Developmental Biology·J E Sulston, H R Horvitz
Mar 29, 1990·Nature·H R SchölerP Gruss
Nov 6, 1998·Science·J A ThomsonJ M Jones
Jul 13, 2001·Current Opinion in Genetics & Development·V Riechmann, A Ephrussi
Jan 7, 2003·Genes & Development·Ariel A AvilionRobin Lovell-Badge
Aug 29, 2003·Development·Toshihiko FujimoriYo-Ichi Nabeshima
Jun 3, 1961·Nature·A K TARKOWSKI
Apr 28, 2004·Molecular Reproduction and Development·Anna ChróścickaMarek Maleszewski
Aug 28, 2004·Nature Structural & Molecular Biology·Attila ReményiMatthias Wilmanns
Mar 18, 2005·Nature·Berenika PlusaMagdalena Zernicka-Goetz
May 10, 2005·Genes & Development·Nami MotosugiTakashi Hiiragi
Aug 22, 2006·Current Opinion in Genetics & Development·Laurie A BoyerRudolf Jaenisch
Jan 12, 2007·Nature·Maria-Elena Torres-PadillaMagdalena Zernicka-Goetz
May 26, 2007·The Journal of Biological Chemistry·Fang WeiMichael L Atchison
Nov 6, 2007·Development·Jens-Erik Dietrich, Takashi Hiiragi
Feb 18, 2009·PloS One·Jonathan P SaxeJing Huang
Jun 19, 2009·Nature Reviews. Genetics·Magdalena Zernicka-GoetzAlexander W Bruce
Feb 19, 2010·Nature·Arjun RajAlexander van Oudenaarden
Jan 25, 2011·Nature Cell Biology·Nicolas PlachtaPeriklis Pantazis

❮ Previous
Next ❯

Citations

Nov 21, 2012·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Atsuo OguraTeruhiko Wakayama
Jun 27, 2014·Reproduction, Fertility, and Development·Michael J BertoldoPascal Mermillod
Sep 1, 2015·Molecular Human Reproduction·Maaike WellingPeriklis Pantazis
Apr 18, 2014·Nature Reviews. Molecular Cell Biology·Periklis Pantazis, Willy Supatto

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Results and Problems in Cell Differentiation
Panagiotis XenopoulosAnna-Katerina Hadjantonakis
Molecular Reproduction and Development
Yusuke Marikawa, Vernadeth B Alarcón
© 2021 Meta ULC. All rights reserved