PMID: 8600030Feb 15, 1996Paper

Transcription factor Spo0A switches the localization of the cell division protein FtsZ from a medial to a bipolar pattern in Bacillus subtilis

Genes & Development
P A Levin, R Losick

Abstract

Entry into sporulation by the Gram-positive bacterium Bacillus subtilis is governed by two transcription factors, Spo0A and sigma H, and involves a switch in the site of division from a medial to a polar location. We report that at the onset of sporulation, assembly of the cell division protein FtsZ shifts from midcell to potential division sites near both poles. The switch to a bipolar pattern of FtsZ localization is dependent on Spo0A. Additionally, synthesis of an activated form of Spo0A during growth artificially activates the switch in FtsZ localization and results in the formation of polar septa. The sigma H factor, on the other hand, is dispensable for the switch in the position of the FtsZ assembly site, although it is required for formation of the polar septum. Our results suggest that during the transition from growth to sporulation, Spo0A induces the expression of genes that suppress FtsZ assembly at the midcell site and activate sites at both poles, whereas sigma H induces genes required for a subsequent step in cytokinesis.

References

Dec 1, 1976·Bacteriological Reviews·P J Piggot, J G Coote
Nov 1, 1977·Journal of General Microbiology·G Dunn, J Mandelstam
Jan 1, 1976·Journal of Bacteriology·A D Hitchins
Apr 20, 1992·Journal of Molecular Biology·G Gonzy-TréboulP Stragier
Oct 1, 1991·Journal of Bacteriology·B SetlowP Setlow
Jan 1, 1991·Methods in Enzymology·J R PringleB K Haarer
May 1, 1990·Journal of Bacteriology·E Bi, J Lutkenhaus
Oct 1, 1985·Cell·J E Ward, J Lutkenhaus
Jan 1, 1986·Annual Review of Genetics·R LosickP J Piggot
Sep 1, 1965·Proceedings of the National Academy of Sciences of the United States of America·P SchaefferJ P Aubert
Oct 1, 1994·Molecular Microbiology·J R McCormickR Losick
Feb 10, 1995·Cell·H P Erickson
Nov 1, 1994·Molecular Microbiology·W R Cook, L I Rothfield
Sep 1, 1994·Trends in Genetics : TIG·J Chant
Apr 26, 1994·Proceedings of the National Academy of Sciences of the United States of America·P J LewisJ Errington
Oct 1, 1993·The Journal of Cell Biology·M M KirkD L Kirk
Aug 1, 1993·Molecular Microbiology·J Lutkenhaus
Jan 1, 1993·Journal of Bacteriology·P S MargolisR Losick
Feb 1, 1993·Journal of Bacteriology·E Bi, J Lutkenhaus

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Citations

Jul 5, 2013·Molecular Genetics and Genomics : MGG·Adam IwanickiMichał Obuchowski
Jul 24, 1998·Trends in Microbiology·W Margolin
Dec 21, 2000·Current Opinion in Microbiology·L Kroos, Y T Yu
Dec 21, 2000·Current Opinion in Microbiology·A L Sonenshein
Dec 4, 2001·Current Opinion in Microbiology·J Errington
Nov 30, 2002·Current Opinion in Microbiology·Joe Lutkenhaus
Mar 6, 1999·Current Opinion in Microbiology·J Lutkenhaus
Mar 6, 1999·Current Opinion in Microbiology·P A Levin, A D Grossman
Mar 2, 2005·Nature Reviews. Microbiology·Esther R Angert
Dec 3, 2005·Nature Reviews. Microbiology·Lawrence RothfieldYu-Ling Shih
Apr 9, 2008·Nature Structural & Molecular Biology·Jerod L PtacinCarlos Bustamante
Jun 11, 1998·Molecular Microbiology·A O HenriquesC P Moran
Apr 12, 2001·Molecular Microbiology·B J HaijemaD Dubnau
Jun 13, 2001·Molecular Microbiology·E J Harry
Mar 12, 2002·Molecular Microbiology·P EichenbergerR Losick
Nov 22, 2012·Proceedings of the National Academy of Sciences of the United States of America·Jatin NarulaOleg A Igoshin
Feb 16, 2002·The EMBO Journal·Sebastien Pichoff, Joe Lutkenhaus
Nov 12, 2002·The EMBO Journal·Marc D Sharp, Kit Pogliano
May 11, 2010·Cold Spring Harbor Perspectives in Biology·David Z Rudner, Richard Losick
Jun 3, 2010·Cold Spring Harbor Perspectives in Biology·Elitza I TochevaGrant J Jensen
Oct 9, 2002·Genes & Development·Frederico J Gueiros-Filho, Richard Losick
Sep 9, 2008·Journal of Bacteriology·José Roberto TavaresFrederico J Gueiros-Filho
Apr 2, 2013·Journal of Bacteriology·David S Weiss
Jun 26, 2012·Journal of Bacteriology·Jennifer K Wagner-HermanDavid Z Rudner
Nov 6, 2007·Journal of Bacteriology·Gonçalo RealJonathan Dworkin
Dec 30, 1999·Journal of Bacteriology·C LuH P Erickson

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