Transcription factorIRX5 promotes hepatocellular carcinoma proliferation and inhibits apoptosis by regulating the p53 signalling pathway.

Cell Biochemistry and Function
Liying ZhuXing Li

Abstract

Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide and the third most frequent cause of cancer-related death. The IRX5 transcription factor plays a different role in multiple cancers and contributes to the development of many tumours. However, little is known about the molecular mechanisms of IRX5 in HCC. In this study, we found that IRX5 was abnormally upregulated in HCC tissues compared with adjacent normal tissues. IRX5 promoted HCC cell proliferation and upregulated the expression of cyclin D1 and knockdown of IRX5 suppressed tumorigenicity in vivo. Furthermore, knockdown of IRX5 increased p53 and Bax expression and decreased Bcl-2 expression. Thus, IRX5 suppressed apoptosis in HCC cells by inhibiting the p53 signalling pathway, indicating its role as a treatment target for HCC. SIGNIFICANCE OF THE STUDY: Our study demonstrated that IRX5 was abnormally upregulated in HCC tissues compared with adjacent normal tissues. IRX5 promoted HCC cell proliferation and upregulated the expression of cyclin D1, and knockdown of IRX5 suppressed tumorigenicity in vivo. Furthermore, knockdown of IRX5 increased p53 and Bax expression and decreased Bcl-2 expression. IRX5 suppressed apoptosis in HCC cells by inhibiting th...Continue Reading

References

May 18, 2001·Nature·G I Evan, K H Vousden
Nov 15, 2002·Cancer Biology & Therapy·J Alan Diehl
Aug 12, 2003·Oncogene·Umberto GalderisiAntonio Giordano
Jul 11, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Rizwan S AkhtarKevin A Roth
Mar 5, 2008·Proceedings of the National Academy of Sciences of the United States of America·Sanjeev ShangaryShaomeng Wang
Jun 4, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Anne MyrthueTomasz M Beer
Sep 4, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sanjeev Shangary, Shaomeng Wang
Nov 21, 2008·Journal of Cell Science·Eric A Klein, Richard K Assoian
Aug 23, 2012·Journal of Biomedicine & Biotechnology·Razmik MirzayansDavid Murray
Nov 5, 2013·Current Medicinal Chemistry·S NagR Zhang
Mar 8, 2014·BioMed Research International·Patrizia BonelliFranco Maria Buonaguro
Dec 14, 2016·Middle East Journal of Digestive Diseases·Nasser AhmadianHamid Reza Joshaghani
Sep 25, 2018·The Journal of Pathology·Linda Holmquist MengelbierDavid Gisselsson
Nov 14, 2018·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Liying ZhuHua Tang
Mar 10, 2019·Biochemical and Biophysical Research Communications·Xia HuGuoqing Zang
Jun 28, 2019·Asian Pacific Journal of Cancer Prevention : APJCP·Ratih Dewi YudhaniMuthmainah Muthmainah

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Citations

Dec 12, 2020·Frontiers in Genetics·Ning LanWenzhen Yuan
Jun 2, 2021·Journal of Cellular and Molecular Medicine·Ping YuYing Chen

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Methods Mentioned

BETA
surgical resections
transfection
electrophoresis
flow cytometry
FACS
Xenograft
xenografts

Software Mentioned

GraphPad
SPSS

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