Transcription factors FOXO in the regulation of homeostatic hematopoiesis

Current Opinion in Hematology
Vijay Menon, Saghi Ghaffari

Abstract

Work in the past decade has revealed key functions of the evolutionary conserved transcription factors Forkhead box O (FOXO) in the maintenance of homeostatic hematopoiesis. Here the diverse array of FOXO functions in normal and diseased hematopoietic stem and progenitor cells is reviewed and the main findings in the past decade are highlighted. Future work should reveal FOXO-regulated networks whose alterations contribute to hematological disorders. Recent studies have identified unanticipated FOXO functions in hematopoiesis including in hematopoietic stem and progenitor cells (HSPC), erythroid cells, and immune cells. These findings suggest FOXO3 is critical for the regulation of mitochondrial and metabolic processes in hematopoietic stem cells, the balanced lineage determination, the T and B homeostasis, and terminal erythroblast maturation and red blood cell production. In aggregate these findings highlight the context-dependent function of FOXO in hematopoietic cells. Recent findings also question the nature of FOXO's contribution to heme malignancies as well as the mechanisms underlying FOXO's regulation in HSPC. FOXO are safeguards of homeostatic hematopoiesis. FOXO networks and their regulators and coactivators in HSPC ...Continue Reading

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Citations

Dec 14, 2018·Journal of Experimental & Clinical Cancer Research : CR·Kun ZhaoMargot Zöller
Sep 20, 2018·F1000Research·Renae J StefanettiSéverine Lamon
Apr 20, 2021·Frontiers in Physiology·Itamar B DiasRobert H Henning

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Methods Mentioned

BETA
acetylation
protein array
transgenic

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