Transcription factors in autoimmune diseases

Current Pharmaceutical Design
Martin EggertG Neeck

Abstract

The analysis of the molecular basis of autoimmune diseases is currently under intense investigation. The identification of novel mechanisms underlying the pathogenesis of these diseases generates the possibility for the development of new therapeutic agents. In this review we summarize the results leading to novel insights concerning the molecular processes involved in the pathogenesis of rheumatoid arthritis, systemic lupus erythematodes, multiple sclerosis and diabetes type 1. We focus on the role of transcription factors such as nuclear factor kappa B, activator protein 1, peroxisome proliferator-activated receptor, vitamin D receptor and the glucocorticoid receptor that mediate pro- and anti-inflammatory effects and therefore represent direct or indirect targets for therapeutic intervention.

Citations

Nov 12, 2005·Parasitology·H S Goodridge, M M Harnett
Aug 13, 2008·Endocrine Reviews·Roger BouillonMarie Demay
Oct 26, 2010·Nutrition·Maria C BorgesMarcelo M Rogero
Jul 16, 2008·Molecular Aspects of Medicine·Femke BaekeChantal Mathieu
Sep 25, 2007·Journal of the Neurological Sciences·Martin EggertUwe K Zettl
Dec 15, 2010·PloS One·Carlos RiverosUNKNOWN ANZgene Multiple Sclerosis Genetics Consortium
Jun 25, 2021·Bioconjugate Chemistry·Christopher J GenitoKristy M Ainslie

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