PMID: 2123539Nov 25, 1990Paper

Transcription factors induced by interferons alpha and gamma

Nucleic Acids Research
A M ImamG R Stark

Abstract

Factors induced by interferons (IFNs) bind to the IFN-stimulated response elements (ISREs) of many genes. In human cells treated with type I (alpha, beta) IFN, factor E is induced in about 1 min and factor M after about 1 hr. Factor G is induced after about 1 hr in cells treated with type II (gamma) IFN. G and M have very similar positions in bandshift assays, sensitivities to cycloheximide, footprints on an ISRE and relative affinities for different ISREs. Four different patterns of expression were observed in different cell lines: E,M and G strongly induced; M and G strongly but E weakly; only E and M induced; only E induced. Transcription in response to IFN alpha is initiated by E and probably maintained by M since, in fibroblasts, M is present maximally when transcription is most active and declines together with transcription. In Bristol-8 cells, where induction of M is not detected, transcription is still induced by IFN alpha and still declines in its continued presence, suggesting that M is not essential for either process. A variant ISRE with two G-to-C mutations binds E especially weakly but M and G strongly. The mutations don't change the response of a reporter gene to IFN gamma but do abolish its response to IFN alph...Continue Reading

Citations

Dec 12, 1997·European Journal of Immunology·L FaggioliM Palmieri
Oct 6, 1998·Annual Review of Biochemistry·G R StarkR D Schreiber
Jun 13, 2000·Oncogene·C V RamanaG R Stark
Jan 23, 1999·International Reviews of Immunology·E De Maeyer, J De Maeyer-Guignard
Jan 1, 1996·Cancer Investigation·D V Kalvakolanu, E C Borden
Aug 26, 1998·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·E W Holmes
Oct 1, 1994·Molecular Reproduction and Development·P J HertzogI Kola
Jul 15, 1991·European Journal of Biochemistry·A R LewinI M Kerr
Jul 22, 1991·FEBS Letters·I M Kerr, G R Stark
Jan 1, 1997·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·M N RutherfordB R Williams
Aug 5, 1998·Proceedings of the National Academy of Sciences of the United States of America·D W LeamanG R Stark
Feb 1, 1995·Molecular and Cellular Biology·V BrikenP Staeheli
Oct 11, 2003·Pharmacology & Therapeutics·Dhananjaya V Kalvakolanu
Dec 15, 2004·Experimental and Molecular Pathology·Gang Zhou, Santa Jeremy Ono

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