Transcription factors SOD7/NGAL2 and DPA4/NGAL3 act redundantly to regulate seed size by directly repressing KLU expression in Arabidopsis thaliana

The Plant Cell
Yueying ZhangYunhai Li

Abstract

Although seed size is one of the most important agronomic traits in plants, the genetic and molecular mechanisms that set the final size of seeds are largely unknown. We previously identified the ubiquitin receptor DA1 as a negative regulator of seed size, and the Arabidopsis thaliana da1-1 mutant produces larger seeds than the wild type. Here, we describe a B3 domain transcriptional repressor NGATHA-like protein (NGAL2), encoded by the suppressor of da1-1 (SOD7), which acts maternally to regulate seed size by restricting cell proliferation in the integuments of ovules and developing seeds. Overexpression of SOD7 significantly decreases seed size of wild-type plants, while the simultaneous disruption of SOD7 and its closest homolog DEVELOPMENT-RELATED PcG TARGET IN THE APEX4 (DPA4/NGAL3) increases seed size. Genetic analyses indicate that SOD7 and DPA4 act in a common pathway with the seed size regulator KLU to regulate seed growth, but do so independently of DA1. Further results show that SOD7 directly binds to the promoter of KLUH (KLU) in vitro and in vivo and represses the expression of KLU. Therefore, our findings reveal the genetic and molecular mechanisms of SOD7, DPA4, and KLU in seed size regulation and suggest that th...Continue Reading

Citations

Oct 3, 2015·Journal of Experimental Botany·Tengbo Huang, Vivian F Irish
Jul 28, 2016·Plant Science : an International Journal of Experimental Plant Biology·Abdelhak FatihiLoïc Lepiniec
Mar 4, 2020·International Journal of Molecular Sciences·Jinshan CaoYouning Wang
Nov 22, 2019·Journal of Experimental Botany·Jasmien VercruysseDirk Inzé
Jul 13, 2017·PloS One·Juliana Joice Pereira LimaOlivier Leprince
Apr 3, 2020·International Journal of Molecular Sciences·Tao GuoLiebao Han
Feb 24, 2019·Annual Review of Plant Biology·Na LiYunhai Li
Nov 7, 2018·Proceedings of the National Academy of Sciences of the United States of America·Hikaru SatoKazuo Shinozaki
Mar 17, 2021·Journal of Genetics and Genomics = Yi Chuan Xue Bao·Tengfei ZhuJun Su
May 1, 2021·International Journal of Molecular Sciences·Javier CanalesDaniel F Calderini
May 2, 2021·Horticulture Research·Umer KaramatJianjun Zhao
Aug 14, 2019·Journal of Agricultural and Food Chemistry·Meng-Jiao LvLai-Sheng Meng

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