Transcription factors Sox5 and Sox6 exert direct and indirect influences on oligodendroglial migration in spinal cord and forebrain

Glia
Tina BarotiC Claus Stolt

Abstract

Transcription factors of the SoxD protein family have previously been shown to prevent precocious specification and terminal differentiation of oligodendrocyte progenitor cells in the developing spinal cord. Using mice with specific deletion of the SoxD proteins Sox5 and Sox6 in the central nervous system, we now show that SoxD proteins additionally influence migration of oligodendrocyte progenitors in the spinal cord as well as in the forebrain. In mutant mice, emigration of oligodendrocyte progenitors from the ventricular zone and colonization of the mantle zone are significantly delayed probably because of reduced expression of Pdgf receptor alpha and decreased responsiveness toward Pdgf-A as a main migratory cue. In addition to this direct cell-autonomous effect on Pdgf receptor alpha expression, SoxD proteins furthermore promote oligodendroglial migration by keeping the cells in an undifferentiated state and preventing a premature loss of their migratory capacity. This indirect effect becomes particularly important during late embryonic and early postnatal phases of oligodendroglial development. Finally, we show that Sox5 and Sox6 cooperate with Sox9 and Sox10 to activate Pdgf receptor alpha expression and thereby maintain...Continue Reading

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Citations

Aug 25, 2016·Seminars in Cell & Developmental Biology·Matthias Weider, Michael Wegner
Sep 3, 2017·Cellular and Molecular Life Sciences : CMLS·Nicolas NaudetRoger Besançon
Jun 5, 2019·International Journal of Molecular Sciences·Jan WittstattMelanie Küspert
May 1, 2019·Glia·Elisabeth Sock, Michael Wegner
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Sep 26, 2020·Archives of Pharmacal Research·Han-Gyu BaeDong-Gyu Jo
Nov 30, 2019·Cellular and Molecular Neurobiology·Guanxiu XiaoMengsheng Qiu
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May 21, 2021·Frontiers in Cell and Developmental Biology·Rachel N Curry, Stacey M Glasgow

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