PMID: 9544570Apr 17, 1998Paper

Transcription factors that regulate monocyte/macrophage differentiation

Journal of Leukocyte Biology
A F ValledorA Celada

Abstract

Although all the cells in an organism contain the same genetic information, differences in the cell phenotype arise from the expression of lineage-specific genes. During myelopoiesis, external differentiating signals regulate the expression of a set of transcription factors. The combined action of these transcription factors subsequently determines the expression of myeloid-specific genes and the generation of monocytes and macrophages. In particular, the transcription factor PU.1 has a critical role in this process. We review the contribution of several transcription factors to the control of macrophage development.

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