Transcription gets to the checkpoint

Cell
John D Laver, Howard D Lipshitz

Abstract

The rapid cell proliferation characteristic of early animal embryos is accomplished with an abbreviated cell cycle and no DNA replication checkpoint. Blythe and Wieschaus provide evidence that nascent zygotic transcription precedes—and may trigger—this checkpoint at the midblastula transition.

Citations

Apr 5, 2018·Journal of Developmental Biology·Fabio Alexis Lefebvre, Éric Lécuyer

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