Transcription of gonadotropin beta subunit genes involves cross-talk between the transcription factors and co-regulators that mediate actions of the regulatory hormones

Molecular and Cellular Endocrinology
Philippa MelamedS Seah

Abstract

The gonadotropins LH and FSH have distinct temporal patterns of expression as a result of differential regulation by hormones such as GnRH, steroids and activin. This specific regulation is due to diverse sets of transcription factors that are recruited to the promoters of these genes, and recruit specific co-activator complexes which function to stabilize interactions with the general transcription factors and RNA polymerase II, and also to induce covalent modifications of the histone tails at these gene loci. As these molecular mechanisms are elucidated, the nature of nuclear cross-talk between the various hormonally induced pathways is becoming evident, revealing both negative and positive effects of interacting transcription factors and co-regulators. This paper will review current knowledge on the transcriptional regulation of gonadotropin beta subunit gene expression in the chromatin setting, and will present new data pertaining to nuclear cross-talk between the various endocrine-induced pathways regulating gonadotropin gene transcription.

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Citations

Oct 23, 2013·Molecular and Cellular Endocrinology·Finn-Arne WeltzienTrude M Haug
Apr 21, 2010·Fertility and Sterility·Daniel J BernardPankaj Lamba
Sep 16, 2008·General and Comparative Endocrinology·Sihui WangPhilippa Melamed
Dec 25, 2007·Trends in Endocrinology and Metabolism : TEM·Philippa Melamed
Sep 1, 2017·Proceedings of the National Academy of Sciences of the United States of America·Yahav YosefzonPhilippa Melamed
Feb 22, 2013·Biology of Reproduction·Daniel J Bernard, Stella Tran
Dec 20, 2014·The Journal of Biological Chemistry·Huizhen WangT Rajendra Kumar
Jul 11, 2012·Journal of Neuroendocrinology·P MelamedL Pnueli
Sep 22, 2020·Molecular and Cellular Endocrinology·Dor Shalev, Philippa Melamed
Jun 7, 2021·Molecular and Cellular Endocrinology·Lilach PnueliPhilippa Melamed
Jun 11, 2021·Endocrinology·Tal Refael, Philippa Melamed
Aug 19, 2008·Frontiers in Neuroendocrinology·Zvi Naor

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