Transcription of the caspase-14 gene in human epidermal keratinocytes requires AP-1 and NFkappaB

Biochemical and Biophysical Research Communications
Claudia BallaunLeopold Eckhart

Abstract

Caspase-14, a protease involved in skin barrier formation, is specifically expressed in epidermal keratinocytes (KCs). Here, we mapped three start sites of transcription of the human caspase-14 gene and analyzed the upstream chromosomal region for promoter activity. Reporter gene assays identified a core promoter region proximal to the first exon and a distal regulatory region which differentially suppressed promoter activity in KC and other cells. Sequence elements in the proximal promoter were bound by the transcription factors AP-1 (JunB, c-Jun, JunD, Fra-1 and Fra-2) and NFkappaB (p50 and RelB). Our data reveal the basic organization of the human caspase-14 promoter and suggest an important role of AP-1 and NFkappaB in the transcriptional control of caspase-14.

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Citations

May 7, 2013·Head and Neck Pathology·Constance ScharenbergKais Hussein
Sep 15, 2009·Reproductive Biology and Endocrinology : RB&E·Lloyd J WhiteArun M Dharmarajan
Apr 13, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yi-Hung WuHungwen Chen
Sep 27, 2014·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Juliana LemoundKais Hussein

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