Transcription of the genome of adenovirus type 12. Viral mRNA in productively infected KB cells.

European Journal of Biochemistry
K H ScheidtmannW Doerfler

Abstract

In human KB cells productively infected with adenovirus type 12, viral DNA replication starts between 12 and 14h postinfection. Virus-specific, polysome-associated mRNA was investigated early (6-8h) and late (26-28h) after infection. Most of the viral mRNA was polyadenylated and accounted for 0.46% and 24.1% of the mRNA synthesized early and late postinfection, respectively. The viral-specific mRNA isolated both early and late after infection falls into several distinct size-classes, ranging in molecular weights between 0.3X10(6) and 1.5X10(6) for the early RNA and between 0.6X10(6) and 2.3X10(6) for the RNA synthesized late in the infection.

References

Jan 1, 1975·Cold Spring Harbor Symposia on Quantitative Biology·L PhilipsonT Persson
Jan 1, 1975·Cold Spring Harbor Symposia on Quantitative Biology·W DoerflerJ Schick
Jun 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·P M McGuireL D Hodge
Jan 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·U PetterssonP A Sharp
Oct 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·J TalH J Raskas
Dec 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·U Pettersson, L Philipson
Sep 1, 1971·Virology·U Lundholm, W Doerfler
Nov 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·L PhilipsonJ E Darnell
Feb 14, 1969·Journal of Molecular Biology·E H McConkey, J W Hopkins
Jun 13, 1966·Biochemical and Biophysical Research Communications·D T Denhardt
Jul 1, 1955·Proceedings of the Society for Experimental Biology and Medicine·H EAGLE

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