PMID: 9450542Feb 5, 1998Paper

Transcription of unr (upstream of N-ras) down-modulates N-ras expression in vivo

FEBS Letters
O BoussadiaF Dautry

Abstract

The ras proteins (Harvey, Kirsten and N-ras) are key regulators of signal transduction and a perturbation of their GDP/GTP cycle is frequently observed in tumors. In mammals, N-ras constitutes with unr (upstream of N-ras) a tightly linked tandem of ubiquitously expressed genes. Although unr and N-ras appear to be involved in distinct functions, this unusual genetic organization could be important for the regulation of N-ras expression. Specifically, transcription of unr could negatively regulate that of N-ras by transcriptional interference. To investigate this possibility, we have deleted the unr promoter by homologous recombination in murine embryonic stem cells. Analysis of tissues of heterozygous mice revealed an increase in N-ras mRNA accumulation ranging between 20 and 65%, in agreement with the suppression of a transcriptional interference.

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Citations

Nov 29, 2015·Biochemical Society Transactions·Emma C Anderson, Pól Ó Catnaigh
Aug 10, 2000·Proceedings of the National Academy of Sciences of the United States of America·R M HuJ L Chen
Feb 21, 2009·Molecular Endocrinology·Juliette RambaudGérard Benoit
Jul 6, 2020·Nucleic Acids Research·Samuele M AmanteRebecca J Oakey
May 27, 2015·Biochemical Society Transactions·Swagat RayEmma C Anderson
Mar 7, 2006·Nature Structural & Molecular Biology·Ann-Bin Shyu
Jan 22, 2010·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Marija MihailovichFátima Gebauer
Nov 14, 2007·Molecular and Cellular Biology·Alexandra C RacanelliRichard G Moran
Jan 3, 2015·Frontiers in Biology·Diana Guallar, Jianlong Wang
Mar 10, 2010·Journal of Structural and Functional Genomics·Alexander K GoroncyShigeyuki Yokoyama
Sep 28, 2018·Cell Communication and Signaling : CCS·Jonathan A Lindquist, Peter R Mertens
Apr 8, 2017·Journal of Cell Science·Frédéric SaltelHélène Jacquemin-Sablon
Feb 7, 2019·G3 : Genes - Genomes - Genetics·Ina HollererGloria A Brar
Aug 11, 2007·Journal of Cell Science·Alexander MazoHugh W Brock
Sep 16, 2000·Cellular Signalling·C A Ellis, G Clark
Oct 12, 2004·Journal of Proteome Research·Henry LuD C Anderson
Mar 17, 2005·Bioconjugate Chemistry·Xiankai SunJohn-Stephen Taylor

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