PMID: 9434159Jan 20, 1998Paper

Transcription rates of SERCA and phospholamban genes change in response to chronic stimulation of skeletal muscle

Biochimica Et Biophysica Acta
P HuF N Briggs

Abstract

Chronic low frequency stimulation of predominantly fast-twitch skeletal muscles decrease the levels of SERCA1 (fast-twitch sarco(endo)plasmic reticulum Ca2+-ATPase) mRNA, and increase the levels of SERCA2 (slow-twitch sarco(endo)plasmic reticulum Ca2+-ATPase) and phospholamban mRNAs. To assess the role of transcription in these changes in mRNA levels, nuclei were isolated from chronically stimulated canine latissimus dorsi muscles and transcription rates were estimated by nuclear run-on assays. Decreases in the rates of SERCA1 gene transcription matched the fall in its mRNA level and increases in the rates of SERCA2 and phospholamban gene transcription matched the increases in their mRNAs.

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Citations

Sep 24, 2005·The Journal of Pathology·Frédéric ChevessierMartine Verdière-Sahuqué
Oct 28, 1998·Physiological Reviews·H K Simmerman, L R Jones
May 18, 1999·The American Journal of Physiology·D G PetersS C Kandarian

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