Transcription regulation of human manganese superoxide dismutase gene

Methods in Enzymology
Daret K St ClairKelley Kiningham

Abstract

The human MnSOD gene has a typical housekeeping gene promoter, but is highly inducible by various physical, chemical, and biological agents. Transcription factors SP-1 and AP-2 seem to have opposite roles in the transcriptional activity of the basal promoter. Whereas SP-1 plays a positive role, which is absolutely essential for transcription from the human MnSOD promoter, AP-2 appears to play a negative role in this process. An enhancer element is found in the promoter region of the human MnSOD gene. Several important enhancer elements are located in the second intron. The NF-kappa B site in the second intron is essential but not sufficient for high-level induction of MnSOD by cytokines. Although mutations in the regulatory elements may be partially responsible for the lack of induction of MnSOD in some cell types, differences in the degree of induction exist that cannot be accounted for by the defect in the DNA sequence. It is highly likely that this difference is due to the presence or absence of coactivator or suppressor proteins in the cells and may have a physiological role in the defense against oxidative stress.

Citations

Jul 20, 2012·Archives of Toxicology·José M MatésJavier Márquez
May 10, 2016·World Journal of Gastroenterology : WJG·Lei LiYa-Chao Yao
Nov 15, 2016·Proceedings of the Japan Academy. Series B, Physical and Biological Sciences·Svetlana DinićMelita Vidaković
Apr 17, 2004·The Journal of Biological Chemistry·Sanjit K DharDaret K St Clair
Oct 7, 2011·Enzyme Research·Chang Li, Hai-Meng Zhou
Jun 25, 2005·Journal of Medical Virology·Maher Y AbdallaBradley E Britigan
Sep 15, 2009·The FEBS Journal·Lukasz SkalniakJolanta Jura
Jul 15, 2017·Journal of Physiology and Biochemistry·Anand Thirupathi, Claudio Teodoro de Souza
Jun 3, 2006·The Journal of Biological Chemistry·Sanjit Kumar DharDaret K St Clair
Feb 19, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jen-Ruey TangClyde J Wright
Nov 11, 2009·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Nandor Gabor ThanGerard Tromp
Apr 4, 2021·Antioxidants·Giuseppina BarreraStefania Pizzimenti
Jul 24, 2004·Differentiation; Research in Biological Diversity·Claudia PopaNicholas A Saunders
May 30, 2009·Free Radical Biology & Medicine·Lu Miao, Daret K St Clair
Jan 21, 2012·Microvascular Research·Tongrong He, Zvonimir S Katusic

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