Transcriptional activation by nuclear receptors

Essays in Biochemistry
Mari Luz Acevedo, W L Kraus

Abstract

Transcriptional activation by nuclear receptors (NRs) involves the recruitment of distinct classes of co-activators and other transcription-related factors to target promoters in the chromatin environment of the nucleus. Chromatin has a general repressive effect on transcription, but also provides opportunities for NRs to regulate transcription by directing specific patterns of chromatin remodelling and histone modification. Ultimately, the transcription of hormone-regulated genes by NRs is critically dependent on co-ordinated physical and functional interactions among the receptors, chromatin, co-activators with chromatin-, histone- and factor-modifying activities, and the RNA polymerase II transcriptional machinery. In addition, several mechanisms exist to terminate or attenuate NR-dependent signalling, including modification, recycling, subcellular redistribution and degradation of the receptors or their associated cofactors. The complexity of NR-dependent transcription provides multiple targets for regulatory inputs, thus allowing each hormone-responsive cell to direct its transcriptional output in a physiologically appropriate manner.

Citations

Jan 12, 2005·Proceedings of the National Academy of Sciences of the United States of America·Edwin CheungW Lee Kraus
Nov 14, 2007·Proceedings of the National Academy of Sciences of the United States of America·June X ZouHong-Wu Chen
Jun 30, 2011·Menopause : the Journal of the North American Menopause Society·Adarsh J SaiXiang Fang
Nov 21, 2009·The Journal of Biological Chemistry·Eric M KofoedFred Schaufele
Feb 13, 2010·Annual Review of Physiology·Edwin Cheung, W Lee Kraus
Dec 17, 2008·World Journal of Gastroenterology : WJG·Aldo-D Mottino, Viviana-A Catania
Mar 28, 2012·Molecular and Cellular Biology·Craig J BurdTrevor K Archer
Jul 27, 2014·Journal of Molecular Endocrinology·Silvia OttavianiLeandro Castellano
Aug 16, 2018·Protein Science : a Publication of the Protein Society·Emily R WeikumEric A Ortlund
Jul 30, 2005·Molecular Endocrinology·Ronald N MargolisUNKNOWN NURSA Atlas Consortium
Jun 14, 2008·PPAR Research·Merja Heinäniemi, Carsten Carlberg
Nov 27, 2020·International Journal of Molecular Sciences·Ankita SahaCraig A Mizzen
Jan 30, 2021·The Biochemical Journal·Martin StortzValeria Levi
Jul 18, 2014·Cellular and Molecular Life Sciences : CMLS·Zhuan ZhouYong Wan
Jan 20, 2007·The Journal of Steroid Biochemistry and Molecular Biology·Carsten CarlbergSami Väisänen
Oct 2, 2007·Dermatologic Clinics·Carsten Carlberg, Sabine Seuter

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