Transcriptional activation of HMGI-C in three pulmonary hamartomas each with a der(14)t(12;14) as the sole cytogenetic abnormality

Cancer Letters
S WanschuraJörn Bullerdiek

Abstract

Aberrations involving the chromosomal region 12q14-15 are non-random cytogenetic abnormalities in many benign tumors, e.g. pulmonary chondroid hamartomas (PCH). Recently, we identified rearrangements of the HMGI-C gene within the third or fourth intron as the molecular mechanism underlying most of these chromosomal aberrations. Herein we report our FISH and RACE studies on three PCHs each showing a rare variant type of the translocation t(12;14)(q14-15;q24) with presence of two normal chromosomes 12 and a der(14) but missing the der(12). The results revealed that in all three cases the breakpoint is located 5' to HMGI-C, suggesting that besides intragenic rearrangements also transcriptional activation of the gene can initiate tumor growth.

References

Jan 1, 1990·Cytogenetics and Cell Genetics·T KievitsP L Pearson
May 1, 1988·Cancer Genetics and Cytogenetics·C Turc-CarelA A Sandberg
May 1, 1988·Cancer Genetics and Cytogenetics·R Vanni, U Lecca
Dec 1, 1986·Cancer Genetics and Cytogenetics·S HeimH Willén
Dec 1, 1994·Cancer Genetics and Cytogenetics·L R Donner
Apr 1, 1995·Cancer Research·P Dal CinH Van den Berghe
Aug 1, 1993·Cancer Genetics and Cytogenetics·C RohenJ Bullerdiek

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Citations

Mar 29, 2002·Genes, Chromosomes & Cancer·Sven HaukeJörn Bullerdiek
Feb 12, 1999·Cancer Genetics and Cytogenetics·P PolitoH Van den Berghe
May 11, 2002·Breast Cancer Research and Treatment·Christine E DoldeLinda M S Resar
Sep 23, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·O SezerK Possinger
May 1, 1997·Cancer Genetics and Cytogenetics·P Dal Cin, H Van den Berghe
Aug 22, 2015·Expert Opinion on Therapeutic Targets·Dominique N MarkowskiJörn Bullerdiek
Feb 3, 1998·Biochemical and Biophysical Research Communications·L V KottickalL Nagarajan
Apr 14, 2005·Seminars in Cancer Biology·Göran Stenman

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