PMID: 6413865Sep 5, 1983Paper

Transcriptional activation of immunoglobulin alpha heavy-chain genes by translocation of the c-myc oncogene

Nature
M DeanG E Sonenshein

Abstract

Our previous studies with the mouse myeloma MOPC 315 (IgA, lambda 2) cell line, using myeloma mutants that had deleted the productive alpha heavy (H)-chain gene, had shown that the excluded alpha constant-region (C alpha) allele in these cells is transcriptionally active. Recent reports from several laboratories have demonstrated that in many BALB/c mouse myelomas, including MOPC 315, the DNA segment encoding the c-myc oncogene is translocated to a C alpha allele. The mRNA coding strand of DNA for the c-myc gene is on the opposite strand from the immunoglobulin gene in this locus. We have now investigated the relationship between the c-myc translocation and transcriptional activity of excluded C alpha alleles in IgA- and IgG-producing mouse myeloma lines. We report here that c-myc-C alpha recombination events correlate with demethylation and transcription of C alpha genes. Several novel C alpha RNA species are produced, which are transcribed from the immunoglobulin-gene sense strand. The larger C alpha RNAs appear to contain c-myc sequences. Thus the anti-sense strand of the c-myc gene provides a promoter for transcription of the C alpha gene. This result suggests that in other transformed cells with a c-myc-immunoglobulin gene...Continue Reading

References

Jul 1, 1978·The Journal of Experimental Medicine·G E SonensheinM L Gefter
Feb 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·A M Maxam, W Gilbert
Jan 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·J L ManleyM L Gefter
Feb 15, 1977·European Journal of Biochemistry·G E Sonenshein, G Brawerman
Jun 13, 1966·Biochemical and Biophysical Research Communications·D T Denhardt
Jan 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·K B MarcuC M Croce
Mar 5, 1981·Nature·A L BothwellD Baltimore
Nov 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·W Dackowski, S L Morrison
Nov 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·J M AdamsS Cory
Oct 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·H KikutaniJ Stavnezer
Dec 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·P W TuckerF R Blattner
Dec 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·R TaubP Leder
May 26, 1983·Nature·M A Boss

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Citations

Oct 1, 1990·Journal of Cellular Physiology·M YaarB A Gilchrest
Jan 15, 1985·Cancer Genetics and Cytogenetics·E Pimentel
Jan 1, 1985·Gene·W DunnickP Szurek
Sep 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·J E McCormackG E Sonenshein
Aug 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·A E Griep, H F DeLuca
Sep 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·L E Dike, S R Farmer
Sep 1, 1992·The British Journal of Dermatology·B A Gilchrest, M Yaar
Apr 1, 1995·Experimental Dermatology·M S EllerB A Gilchrest
Aug 5, 2003·Molecular and Cellular Biology·Raphaëlle Romieu-MourezGail E Sonenshein
Oct 1, 1994·The Journal of Clinical Investigation·M YaarB A Gilchrest
Aug 29, 1986·Cell·D G BlairG F Vande Woude
Oct 9, 2014·The Journal of Pathology·Martina VockerodtPaul G Murray
Feb 1, 1986·Immunological Reviews·P D GregorS L Morrison
Sep 6, 2011·Cell·Jake E DelmoreConstantine S Mitsiades
Dec 24, 2004·The Journal of Biological Chemistry·Claudia S HofmannGail E Sonenshein
May 4, 2017·Cell Cycle·Matthieu SchoenhalsJérôme Moreaux
Jan 15, 1989·International Journal of Cancer. Journal International Du Cancer·A GreenbergR Laskov
Dec 5, 1998·Microbiology and Molecular Biology Reviews : MMBR·M Kumar, G G Carmichael
Feb 1, 1987·Molecular and Cellular Biology·M DeanG F Vande Woude
Aug 1, 1987·Molecular and Cellular Biology·M S KindyG E Sonenshein
Aug 1, 1990·Molecular and Cellular Biology·G W KrystalJ F Battey
Mar 1, 1992·Molecular and Cellular Biology·D B Spicer, G E Sonenshein
Feb 1, 1993·The Journal of Investigative Dermatology·S SanquerB A Gilchrest
Feb 1, 1992·Experimental Cell Research·M S EllerB A Gilchrest
Nov 1, 1987·Experimental Cell Research·V VollochS Rits

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