Abstract
In this study, we determined whether the DDT isomers p,p'-DDT [1,1,1,-trichloro-2,2-bis(p-chlorophenyl)ethane], o,p'-DDT [1,1,1-trichloro-2(p-chlorophenyl)-2-(o-chlorophenyl)ethane], and their metabolites p,p'-DDD [1,1-dichloro-2,2-bis(p-chlorophenyl)ethane], o,p'-DDD [1,1-dichloro-2-(p-chlorophenyl)-2-(o-chlorophenyl)ethane], p,p'-DDE [1,1,-dichloro-2,2-bis(p-chlorophenyl)ethylene], o,p'-DDE [1,1-dichloro-2-(p-chlorophenyl)-2-(o-chlorophenyl)ethylene], and p,p'-DDA [2,2-bis(p-chlorophenyl)acetic acid], could bind to and transcriptionally activate the human estrogen receptor (hER). Novel results from competitive binding assays showed that o,p'-DDD, o,p'-DDE, and p,p'-DDT, as well as the established environmental estrogen o,p'-DDT, were able to bind specifically to the hER with approximately 1000-fold weaker affinities for the hER than that of estradiol. In contrast, only o,p'-DDT, but not p,p'-DDT, bound to the rat estrogen receptor. Moreover, two yeast expression-reporter systems, constructed to test if the DDT isomers and metabolites could transcriptionally activate the hER, demonstrated that an o,p'-DDT metabolite could transactivate the hER or LexA-hER fusion protein with just a 140- to 300-fold weaker potency than that of ...Continue Reading
References
Mar 1, 1978·Journal of Toxicology and Environmental Health·J A NelsonR James
Aug 1, 1992·The Journal of Steroid Biochemistry and Molecular Biology·C R LyttleT R Butt
May 1, 1991·Bulletin of Environmental Contamination and Toxicology·K SasakiM Uchiyama
Jan 1, 1992·Current Genetics·D C ChenT T Kuo
Apr 15, 1991·The Science of the Total Environment·H Mussalo-Rauhamaa
Sep 1, 1991·The Journal of Steroid Biochemistry and Molecular Biology·D P McDonnellB W O'Malley
Feb 1, 1990·Endocrinology·B S Katzenellenbogen, M J Norman
Oct 1, 1988·Molecular Endocrinology·C A WeaverB S Katzenellenbogen
Sep 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·P SungS Prakash
Oct 1, 1988·Journal of Steroid Biochemistry·A E Wakeling, J Bowler
Jul 7, 1988·Nature·D MetzgerP Chambon
Mar 1, 1987·The Journal of Endocrinology·A E Wakeling, J Bowler
Sep 1, 1985·Toxicology Letters·A K RobisonG M Stancel
Jan 15, 1974·Biochemical Pharmacology·J A Nelson
Jul 1, 1974·Archives of Environmental Health·D P Morgan, C C Roan
Nov 1, 1970·Journal of Agricultural and Food Chemistry·J Bitman, H C Cecil
Oct 18, 1968·Science·J BitmanG F Fries
Mar 1, 1969·Toxicology and Applied Pharmacology·R M WelchA H Conney
Jan 1, 1981·Carcinogenesis·J D Scribner, N K Mottet
Jun 15, 1995·Nature·W R KelceE M Wilson
Mar 1, 1995·Endocrinology·J R ZyskJ Gorski
Oct 1, 1994·Steroids·H KohnoK S Korach
Apr 1, 1994·Environmental Health Perspectives·A M SotoC Sonnenschein
Jul 15, 1994·Science·R Stone
Oct 1, 1993·Environmental Health Perspectives·T ColbornA M Soto
Feb 1, 1994·Current Genetics·F Prado, A Aguilera
Oct 1, 1993·Environmental Health Perspectives·D L DavisH Anton-Culver
Mar 1, 1994·The Journal of Steroid Biochemistry and Molecular Biology·M BorrásG Leclercq
Mar 1, 1994·Bulletin of Environmental Contamination and Toxicology·J K Ludwicki, K Góralczyk
Jun 10, 1994·Gene·B PierratR Losson
Dec 1, 1993·The Journal of Steroid Biochemistry and Molecular Biology·B S KatzenellenbogenC K Wrenn
Jun 22, 1993·Biochemistry·J D ObournA C Notides
Jun 7, 1996·Science·S F ArnoldJ A McLachlan
May 1, 1996·Environmental Health Perspectives·S F ArnoldJ A McLachlan
Citations
Jul 28, 2011·Environmental Science and Pollution Research International·Bernhard WetterauerHenner Hollert
Mar 9, 2004·Aquatic Toxicology·Hiroshi IshibashiKoji Arizono
Mar 18, 2004·The Journal of Steroid Biochemistry and Molecular Biology·Nariaki FujimotoShigeyuki Kitamura
May 17, 2005·The Science of the Total Environment·John Beard, UNKNOWN Australian Rural Health Research Collaboration
Apr 15, 2004·Toxicology and Applied Pharmacology·Géraldine LemaireRoger Rahmani
May 25, 2001·Chemosphere·C S McMurry, R L Dickerson
Jul 3, 1999·Chemosphere·K RehmannA A Kettrup
Aug 9, 2002·Toxicology·Liliane-Eustache OkoumassounFrancine Denizeau
May 29, 2000·Reproductive Toxicology·D B TullyR E Chapin
Jun 6, 2000·Reproductive Toxicology·A R GreenleeR L Berg
Dec 29, 1999·Reproductive Toxicology·A R GreenleeR L Berg
Aug 12, 1998·The Journal of Steroid Biochemistry and Molecular Biology·E CastañoA C Notides
Dec 10, 1997·Journal of the National Cancer Institute·N E Davidson, J D Yager
May 6, 2006·Environmental Health : a Global Access Science Source·Eva C Bonefeld-JorgensenJens Peter Bonde
Jul 25, 2006·Breast Cancer Research : BCR·Mónica Muñoz-de-ToroEnrique H Luque
Aug 31, 2000·Environmental Health Perspectives·H FangD M Sheehan
Feb 5, 2000·Environmental Health Perspectives·C Q SheelerS A Khan
Aug 4, 2001·Environmental Health Perspectives·P De BoeverW Verstraete
Mar 14, 2003·Environmental Health Perspectives·M M MumtazC T De Rosa
Jan 6, 2010·Environmental Health Perspectives·Christophe MorisseauBruce D Hammock
Mar 4, 2003·Environmental Health Perspectives·Shigeyuki KitamuraShigeru Ohta
Apr 5, 2003·Environmental Health Perspectives·Hiroyuki KojimaKunihiko Kobayashi
Apr 5, 2003·Environmental Health Perspectives·Shigeyuki KitamuraNariaki Fujimoto
Jun 27, 2003·Environmental Health Perspectives·Christopher J BorgertRaphael J Witorsch
Oct 11, 2003·Environmental Health Perspectives·Ruth H MilstonCarl B Schreck
May 7, 1999·Environmental Health Perspectives·H R AndersenA M Soto
Sep 12, 2003·Emerging Infectious Diseases·Aimin Chen, Walter J Rogan
Oct 24, 2000·General and Comparative Endocrinology·C W BreunerM Orchinik
Jan 13, 2009·Chemosphere·Fei LiXianliang Qiao
May 4, 2007·Toxicology and Applied Pharmacology·Olga Leaños-CastañedaG Gold
Aug 6, 2013·Environmental Toxicology·Diogo PestanaConceição Calhau
Aug 15, 2012·Environmental Toxicology and Chemistry·Shulin ZhuangWeiping Liu
Feb 9, 2005·The Journal of Steroid Biochemistry and Molecular Biology·André SievernichHella Lichtenberg-Fraté
Apr 7, 2016·Environmental Pollution·Jordan CragoDaniel Schlenk
Jun 11, 2002·Biochemical and Biophysical Research Communications·Shigeyuki KitamuraNariaki Fujimoto
Jul 21, 2004·Environmental Pollution·Tatsuya KunisueShinsuke Tanabe
Mar 28, 2006·Environmental Pollution·H BouwmanH M Meinhardt
Aug 26, 1998·Toxicology and Applied Pharmacology·S C ManessK W Gaido
May 3, 2000·Medical Hypotheses·K Jaga
Aug 11, 2000·Toxicology and Applied Pharmacology·K SugiharaA Ito
Oct 21, 2016·Environmental Research·Joan FornsMerete Eggesbø
Jul 31, 2016·Fertility and Sterility·Sacha A KriegRuth B Lathi
Apr 3, 2014·Environmental Science & Technology·Shinichi MiyagawaTaisen Iguchi
Dec 2, 2008·Chemosphere·R Dahmardeh BehroozS M Ghasempouri
Mar 30, 2002·Cadernos de saúde pública·Pierluigi Cocco
Mar 12, 2009·Veterinary Pathology·K M ColegroveL J Lowenstine
May 19, 2018·Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes·Marek RoszkoBeata Chabłowska
Sep 22, 2017·Environmental Health Perspectives·German Cano-SanchoMichele A La Merrill
Aug 5, 1999·Endocrinology·D GhoshD B Lubahn
Jul 25, 2000·Archives of Environmental Health·J BeardR Bronks