Transcriptional activation of the IL-6 response element in the junB promoter is mediated by multiple Stat family proteins

Biochemical and Biophysical Research Communications
Y FujitaniT Hirano

Abstract

IL-6 signals activate an IL-6 response element in the junB promoter, JRE-IL6, in a Ras-independent manner. IL-6 rapidly induced a DNA-binding activity to the Ets binding site of JRE-IL6 (JEBS), one of necessary DNA motifs of the IL-6 response element. The IL-6-induced JEBS-binding activity was indistinguishable from those to acute phase response element (APRE) in both kinetics of induction and its DNA-binding specificity. Purified APRE binding factors (APRFs) from IL-6-stimulated rat liver were found to be composed of multiple Stat3-related proteins and Stat1. Moreover the purified APRFs specifically made a complex with JRE-IL6 with the same mobility as that observed in the crude extracts. These results indicate that an immediate early signal of IL-6 leading to activation of JRE-IL6 is mediated by STAT family transcription factors.

Citations

Nov 30, 2012·Journal of Inflammation·Sorina Georgiana BoaruRalf Weiskirchen
Apr 12, 2011·Cytokine·Marissa K CaldowDavid Cameron-Smith
Mar 10, 2004·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Natsuko HigashiKoichi Nakajima
Jun 15, 2004·Biochemical and Biophysical Research Communications·Shin-Ichi GorogawaMasatsugu Hori
Nov 9, 2004·Biochemical and Biophysical Research Communications·Hong ZhaoKoichi Nakajima
Oct 7, 2011·Cytokine & Growth Factor Reviews·Anna TarasovaDavid Winkler
Mar 20, 1998·International Reviews of Immunology·T Hirano
Apr 30, 2004·Oncogene·Haiyun Y ChengMichael W Lieberman
Feb 15, 2001·Oncogene·V I Sementchenko, D K Watson
Nov 22, 2005·Oncogene·Matthew D Weitzman, David A Ornelles
Mar 1, 2005·Oncogene·Daniel J DauerEric B Haura
Oct 6, 1995·The Journal of Biological Chemistry·K NakaeT Hirano
Mar 11, 1999·Journal of Receptor and Signal Transduction Research·M H Heim
Dec 31, 1997·The American Journal of Physiology·S WangB M Evers
Apr 1, 2000·Cytokine & Growth Factor Reviews·P M GrimleyH Rui
Jun 10, 1998·Cytokine & Growth Factor Reviews·T HiranoM Hibi

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