Transcriptional activity and constitutive nuclear localization of the ETS protein Elf-1

FEBS Letters
I Bredemeier-ErnstR Janknecht

Abstract

Elf-1 is a lymphoid-specific transcription factor that belongs to the ETS protein family. It can bind to DNA target sequences within a variety of cytokine genes. We demonstrate that Elf-1 is constitutively localized in the nucleus which is dependent on the presence of amino acids 86-265. Analysis of Gal4-Elf-1 fusion proteins revealed that the N-terminal 86 amino acids of Elf-1 contain a transcriptional activation domain, the activity of which is attenuated by an internal repression domain. Furthermore, Elf-1 interacts specifically with the E74 target sequence and can stimulate transcription driven by the E74 site independent of mitogenic signaling. Thus, Elf-1 is able to stimulate gene transcription which may be required for the development and activity of lymphocytes.

References

Oct 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·A SethT S Papas
Jan 21, 1988·Nature·F Moreau-GachelinP Tambourin
Mar 1, 1995·Carcinogenesis·R JanknechtA Nordheim
Oct 1, 1994·Molecular and Cellular Biology·A L WursterS M Hedrick
Dec 23, 1993·Biochimica Et Biophysica Acta·R Janknecht, A Nordheim
Jan 15, 1993·European Journal of Biochemistry·B WasylykA Giovane
Sep 1, 1996·Molecular and Cellular Biology·P OettgenT A Libermann
Oct 18, 1996·The Journal of Biological Chemistry·Y AkbaraliT A Libermann
Nov 1, 1996·Molecular and Cellular Biology·P ErnstS T Smale

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Citations

Jul 12, 2002·Journal of Cellular Biochemistry·Denis G Bosc, Ralf Janknecht
Jun 12, 2003·Gynecologic Oncology·Noriyuki TakaiIsao Miyakawa
Aug 2, 2002·Biochimica Et Biophysica Acta·Mary Ann SuicoHirofumi Kai
Feb 15, 2000·Biochimica Et Biophysica Acta·K L PearsonR Janknecht
Jul 3, 2002·Bioscience, Biotechnology, and Biochemistry·Chiharu NishiyamaChisei Ra
Jan 23, 2016·Journal of Computational Biology : a Journal of Computational Molecular Cell Biology·Yifeng LiWyeth W Wasserman
Feb 15, 2001·Oncogene·G K ScottC C Benz
Sep 4, 2004·Clinical Orthopaedics and Related Research·Bruno FuchsR Janknecht
Mar 7, 2020·Scientific Reports·Marianne S AndresenGrethe Skretting
Feb 24, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Bruno FuchsRalf Janknecht

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