Transcriptional activity of oestrogen receptors in the course of embryo development

The Journal of Endocrinology
Sara Della TorreAdriana Maggi

Abstract

Oestrogens are well-known proliferation and differentiation factors that play an essential role in the correct development of sex-related organs and behaviour in mammals. With the use of the ERE-Luc reporter mouse model, we show herein that throughout mouse development, oestrogen receptors (ERs) are active starting from day 12 post conception. Most interestingly, we show that prenatal luciferase expression in each organ is proportionally different in relation to the germ layer of the origin. The luciferase content is highest in ectoderm-derived organs (such as brain and skin) and is lowest in endoderm-derived organs (such as liver, lung, thymus and intestine). Consistent with the testosterone surge occurring in male mice at the end of pregnancy, in the first 2 days after birth, we observed a significant increase in the luciferase content in several organs, including the liver, bone, gonads and hindbrain. The results of the present study show a widespread transcriptional activity of ERs in developing embryos, pointing to the potential contribution of these receptors in the development of non-reproductive as well as reproductive organs. Consequently, the findings reported here might be relevant in explaining the significant diffe...Continue Reading

References

May 1, 1977·Endocrinology·M S BarkleyG E Bradford
May 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·K S KorachJ A McLachlan
Feb 15, 1985·American Journal of Obstetrics and Gynecology·A Thuresson-KleinP Hedqvist
Jun 1, 1966·Proceedings of the National Academy of Sciences of the United States of America·D Toft, J Gorski
Jan 1, 1994·Annual Review of Biochemistry·M J Tsai, B W O'Malley
Dec 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·D B LubahnO Smithies
Jan 1, 1997·Endocrinology·E F RissmanD B Lubahn
Feb 1, 1997·Mammalian Genome : Official Journal of the International Mammalian Genome Society·A I AgulnikV V Solovyev
Jun 17, 1998·Proceedings of the National Academy of Sciences of the United States of America·C R FisherE R Simpson
Dec 23, 1998·Proceedings of the National Academy of Sciences of the United States of America·J H KregeO Smithies
May 20, 1999·Mechanisms of Development·J G LemmenB van der Burg
May 4, 2000·Journal of Reproduction and Fertility·M NielsenA G Byskov
Nov 9, 2000·Proceedings of the National Academy of Sciences of the United States of America·M E JonesE R Simpson
Sep 27, 2001·The Journal of Endocrinology·M Campbell-ThompsonL B Wilkinson
Dec 17, 2002·Nature Medicine·Paolo CianaAdriana Maggi
Feb 24, 2004·Annual Review of Physiology·Adriana MaggiElisabetta Vegeto
Sep 30, 2004·ILAR Journal·Vickie R Walker, Kenneth S Korach
Feb 12, 2005·Science·Chetana M RevankarEric R Prossnitz
Mar 2, 2005·Nature Reviews. Drug Discovery·Adriana Maggi, Paolo Ciana
Sep 7, 2005·Cell·Annette HammesThomas E Willnow
Sep 13, 2005·The Journal of Steroid Biochemistry and Molecular Biology·Michael HümpelWolf-Dieter Schleuning
Jun 6, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Allison L Zoller, Gilbert J Kersh
Oct 27, 2006·Proceedings of the National Academy of Sciences of the United States of America·Paola MussiBert W O'Malley
Nov 11, 2006·American Journal of Respiratory and Critical Care Medicine·Michelle A CareyDarryl C Zeldin
Nov 30, 2006·Pharmacological Reviews·Karin Dahlman-WrightJan-Ake Gustafsson
Jan 15, 2009·Nephron. Experimental Nephrology·Kenneth A WalkerKerry J McInnes

❮ Previous
Next ❯

Citations

Dec 14, 2019·The European Journal of Neuroscience·Badr KhbouzCharlotte A Cornil
May 19, 2021·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Barbara HammerSusanne Krauss-Etschmann

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Ernst Schering Research Foundation Workshop
P CianaAdriana Maggi
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Per E Lønning, Mitch Dowsett
© 2022 Meta ULC. All rights reserved