Transcriptional alteration of p53 related processes as a key factor for skeletal muscle characteristics in Sus scrofa

Molecules and Cells
Seung-Soo KimCheol-Koo Lee

Abstract

The pig could be a useful model to characterize molecular aspects determining several delicate phenotypes because they have been bred for those characteristics. The Korean native pig (KNP) is a regional breed in Korea that was characterized by relatively high intramuscular fat content and reddish meat color compared to other western breeds such as Yorkshire (YS). YS grew faster and contained more lean muscle than KNP. We compared the KNP to Yorksire to find molecular clues determining muscle characteristics. The comparison of skeletal gene expression profiles between these two breeds showed molecular differences in muscle. We found 82 differentially expressed genes (DEGs) defined by fold change (more than 1.5 fold difference) and statistical significance (within 5% of false discovery rate). Functional analyses of these DEGs indicated up-regulation of most genes involved in cell cycle arrest, down-regulation of most genes involved in cellular differentiation and its inhibition, down-regulation of most genes encoding component of muscular-structural system, and up-regulation of most genes involved in diverse metabolism in KNP. Especially, DEGs in above-mentioned categories included a large number of genes encoding proteins direct...Continue Reading

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Citations

Mar 11, 2011·Bioscience, Biotechnology, and Biochemistry·Seung-Soo KimCheol-Koo Lee
Jan 13, 2018·International Journal of Molecular Sciences·Michael Hadjiargyrou
Nov 2, 2018·Biomechanics and Modeling in Mechanobiology·Annalisa CanovettiPaolo Ferrara
Dec 17, 2014·Politics and the Life Sciences : the Journal of the Association for Politics and the Life Sciences·Alisa Von Hagel
Feb 25, 2017·The American Journal of Chinese Medicine·Sijia FangGuang Ji

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